The Bidirectional Effects of Periodontal Disease and Oral Dysbiosis on Gut Inflammation in Inflammatory Bowel Disease

• Published in: Journal of Crohn's and colitis Vol. 19; no. 4
• Main Authors: Zilberstein, Netanel F, Engen, Phillip A, Swanson, Garth R, Naqib, Ankur, Post, Zoe, Alutto, Julian, Green, Stefan J, Shaikh, Maliha, Lawrence, Kristi, Adnan, Darbaz, Zhang, Lijuan, Voigt, Robin M, Schwartz, Joel, Keshavarzian, Ali
• Format: Journal Article
• Language: English
• Published: England 04.04.2025
• Subjects: Adult; Case-Control Studies; Cross-Sectional Studies; Dysbiosis - complications; Dysbiosis - microbiology; Feces - microbiology; Female; Gastrointestinal Microbiome; Humans; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - microbiology; Male; Middle Aged; Mouth - microbiology; Oral Hygiene; Periodontal Diseases - complications; Periodontal Diseases - epidemiology; Periodontal Diseases - microbiology; Prospective Studies; RNA, Ribosomal, 16S; Saliva - microbiology; microbiota; oral hygiene; inflammatory bowel disease; periodontal disease; dysbiosis
• ISSN: 1873-9946; 1876-4479; 1876-4479
• DOI: 10.1093/ecco-jcc/jjae162

Inflammatory bowel disease (IBD) flares can lead to excessive morbidity and mortality. This study aimed to determine whether oral dysbiosis/periodontal disease (PD) is common in IBD and is associated with disease activity in IBD. This single-center, prospective, cross-sectional, proof-of-concept, an...