Histologic predictors of kidney outcomes in LN: re-evaluating the role of segmental glomerulosclerosis in the chronicity index

• Published in: Rheumatology (Oxford, England) Vol. 64; no. 8; pp. 4787 - 4795
• Main Authors: Tinajero-Sánchez, Denisse N, Zúñiga-González, Erick Y, Zavala-Miranda, María F, Hernández-Andrade, Adriana, Navarro-Sánchez, Valeria, Nordmann-Gomes, Alberto, Rivero-Otamendi, Emiliano, Uribe-Uribe, Norma O, Mejia-Vilet, Juan M
• Format: Journal Article
• Language: English
• Published: England Oxford Publishing Limited (England) 01.08.2025
• Subjects: Adult; Atrophy; Biopsy; Disease Progression; End-stage renal disease; Female; Fibrosis; Glomerulosclerosis, Focal Segmental - pathology; Humans; Kidney - pathology; Kidney diseases; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - pathology; Lesions; Lupus Nephritis - complications; Lupus Nephritis - drug therapy; Lupus Nephritis - pathology; Male; Middle Aged; Prognosis; Remission; Sclerosis; chronicity index; LN; activity index; prognosis; ISN/RPS classification
• ISSN: 1462-0324; 1462-0332
• DOI: 10.1093/rheumatology/keaf194

There is a call to improve the histological classification of LN. We assessed the association between histological lesions and kidney outcomes. We assessed 430 participants with biopsy-proven LN diagnosed between 2008 and 2020. All participants had follow-up for ≥3 years. The activity and chronicity...