Hyaluronic acid covalently grafted graphene oxide stably targets the natural cartilage friction interface for achieving long-term wear resistance

• Published in: Wear Vol. 578-579; p. 206156
• Main Authors: Yuan, Ziji, Ma, Teng, He, Xiaofan, Fang, Ying, Wu, Liangbin, Wu, Qian, Li, Chuanrun, Peng, Chengjun, Wu, Bo
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.09.2025
• Subjects: Articular cartilage; Exogenous lubricants; Targeting interface; Tribological properties; Wear resistance mechanism; Articular cartilage; Targeting interface; Tribological properties; Wear resistance mechanism; Exogenous lubricants

The exploitation of long-acting intra-articular lubricants is significantly important for the treatment of early osteoarthritis. Herein, we developed a novel exogenous cartilage lubricant (HAGO) with an excellent long-term wear resistance property by covalently grafting clinically used hyaluronic ac...