Recent advances in catalysts for the Henry reaction

The Henry reaction, the coupling of a nitro alkane and a carbonyl group, is an important C–C bond-forming reaction giving nitro alkanols, which are useful, versatile intermediates in synthetic organic chemistry and for the pharmaceutical industry. Among the catalysts employed in the Henry reaction,...

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Bibliographic Details
Published inAustralian journal of chemistry Vol. 75; no. 10; pp. 806 - 819
Main Authors Bao, Xuefei, Li, Xu, Jiang, Chunfeng, Xiao, Wei, Chen, Guoliang
Format Journal Article
LanguageEnglish
Published Collingwood CSIRO 08.11.2022
Subjects
Aldehydes
Alkanes
Carbonyl groups
Carbonyls
Catalysts
Chemical bonds
Coordination compounds
Copper
Covalent bonds
Ligands
Nanoparticles
Organic chemistry
Transition metal compounds
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Summary:The Henry reaction, the coupling of a nitro alkane and a carbonyl group, is an important C–C bond-forming reaction giving nitro alkanols, which are useful, versatile intermediates in synthetic organic chemistry and for the pharmaceutical industry. Among the catalysts employed in the Henry reaction, transition metal complex catalysts play an important role. Transition metal complexes, including small molecules and nanoparticles, catalyze the asymmetric Henry reaction efficiently and in most of the cases give chiral nitro alkanol products in good yield and enantiomeric excess. This review summarizes transition metal complex catalysts, metal-free organic catalysts and nanoparticle catalysts for the Henry reaction.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 14
ISSN:0004-9425
1529-5036
1445-0038
DOI:10.1071/CH22136