Low-molecular weight components of cow colostrum regulate bone marrow functions by modelling the redox-system of the organism
Colostrum is rich in various biologically active compounds such as immunotropic ones. Low molecular weight components were isolated from cow colostrum components (with a molecular weight of not more than 45 kDa). Their influence was investigated on intact Wistar Rattus norvegicus adult males in conc...
Saved in:
Published in | Regulatory mechanisms in biosystems Vol. 11; no. 2; pp. 272 - 277 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oles Honchar Dnipro National University
01.01.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Colostrum is rich in various biologically active compounds such as immunotropic ones. Low molecular weight components were isolated from cow colostrum components (with a molecular weight of not more than 45 kDa). Their influence was investigated on intact Wistar Rattus norvegicus adult males in concentrations of 0.01, 0.1, 1.0 and 5.0 g/100 g of body weight. We determined content of lipid hydroperoxides and activity of serum glutathione peroxidase in blood serum, parameters of the bone marrow cells’ (BMCs) behaviour in the in vitro system (proliferation ability, morphologically identifiable and unidentifiable type of cells, lifespan of eosinophils). Morphological identifiable cells were stab neutrophils, segmented neutrophils, metamyelocytes, myelocytes, lymphocytes, basophils, neutrophils, eosinophils, monocytes. The low doses of colostrum components (0.01–0.10 g/100 g of body weight) did not affect the ratio of morphologically identifiable/unidentifiable cells. Administration of colostrum components at low doses (0.01 g/100 g of weight) increased the ability of BMCs to proliferate in the in vitro system. A super-large dose of colostrum components (5 g/100 g of body weight) was accompanied by a further loss of capacity for proliferation and cell death. Moreover, large doses of colostrum components resulted in change of balance to prooxidants (oxidants). The role of redox – system in BMCs functions was discussed. Large doses of colostrum components (1–5 g/100 g of body weight) were accompanied by a change of pro-antioxidant system balance. Only eosinophils were determined after administration of colostrum components in a large dose. It should be noted that the lifetime of eosinophils which developed under influence of colostrum components was greater than that of eosinophils obtained from control animals. |
---|---|
AbstractList | Colostrum is rich in various biologically active compounds such as immunotropic ones. Low molecular weight components were isolated from cow colostrum components (with a molecular weight of not more than 45 kDa). Their influence was investigated on intact Wistar Rattus norvegicus adult males in concentrations of 0.01, 0.1, 1.0 and 5.0 g/100 g of body weight. We determined content of lipid hydroperoxides and activity of serum glutathione peroxidase in blood serum, parameters of the bone marrow cells’ (BMCs) behaviour in the in vitro system (proliferation ability, morphologically identifiable and unidentifiable type of cells, lifespan of eosinophils). Morphological identifiable cells were stab neutrophils, segmented neutrophils, metamyelocytes, myelocytes, lymphocytes, basophils, neutrophils, eosinophils, monocytes. The low doses of colostrum components (0.01–0.10 g/100 g of body weight) did not affect the ratio of morphologically identifiable/unidentifiable cells. Administration of colostrum components at low doses (0.01 g/100 g of weight) increased the ability of BMCs to proliferate in the in vitro system. A super-large dose of colostrum components (5 g/100 g of body weight) was accompanied by a further loss of capacity for proliferation and cell death. Moreover, large doses of colostrum components resulted in change of balance to prooxidants (oxidants). The role of redox – system in BMCs functions was discussed. Large doses of colostrum components (1–5 g/100 g of body weight) were accompanied by a change of pro-antioxidant system balance. Only eosinophils were determined after administration of colostrum components in a large dose. It should be noted that the lifetime of eosinophils which developed under influence of colostrum components was greater than that of eosinophils obtained from control animals. |
Author | Ohiienko, S. L. Ivanov, E. G. Bozhkov, A. I. Kurguzova, N. I. Bondar, A. Y. |
Author_xml | – sequence: 1 givenname: A. I. orcidid: 0000-0001-8418-5716 surname: Bozhkov fullname: Bozhkov, A. I. – sequence: 2 givenname: S. L. orcidid: 0000-0002-7876-8701 surname: Ohiienko fullname: Ohiienko, S. L. – sequence: 3 givenname: A. Y. orcidid: 0000-0001-6231-3289 surname: Bondar fullname: Bondar, A. Y. – sequence: 4 givenname: E. G. orcidid: 0000-0001-6992-9406 surname: Ivanov fullname: Ivanov, E. G. – sequence: 5 givenname: N. I. orcidid: 0000-0002-3459-8114 surname: Kurguzova fullname: Kurguzova, N. I. |
BookMark | eNo9kctqwzAQRUVJoWka-gvadeVWki17vCyhj0Cgm3Zt9HQcbCtICqkX_fcqSelimMe9HAbuLZqNbjQI3VPySHnB6BNhjBTkCs0ZZyRjHGB2mmmdAWf0Bi1D2BFCKACtaDVHPxt3zAbXG3XohcdH07XbiJUb9gk8xoCdTdsxVe9C9IcBe9MmazRYJgcehPdJtodRxc6NAcsJD06bvu_GFsetSX7tvrMwhWiGE-10c74VYxeGO3RtRR_M8q8v0Nfry-fqPdt8vK1Xz5tMMZ7HTHFDSA62krSEmkpWWWF1rakojLQgpMnLquRFrTVjouACoJSktjJPgi1VvkDrC1c7sWv2vktvT40TXXM-pHca4WOnetMwgISqKFeJDnlRUyC1IACaS6llmVgPF5byLgRv7D-PkuYcQnMJIf8F5UZ8tw |
Cites_doi | 10.1111/nure.12089 10.1038/nature09262 10.1016/j.stemcr.2018.06.007 10.1007/BF02540959 10.1515/jcim-2014-0039 10.1038/227680a0 10.11648/j.ajbls.s.2014020601.15 10.1002/biof.1339 10.1634/stemcells.22-6-962 10.1073/pnas.1620059114 10.1007/s11515-017-1458-y 10.1016/j.micpath.2016.12.007 10.6000/1929-5634.2017.06.04.2 10.1016/j.bbrc.2017.04.011 10.6000/1929-5634.2017.06.01.2 10.1016/j.exphem.2004.02.004 |
ContentType | Journal Article |
DBID | AAYXX CITATION DOA |
DOI | 10.15421/022040 |
DatabaseName | CrossRef DOAJ Directory of Open Access Journals |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2520-2588 |
EndPage | 277 |
ExternalDocumentID | oai_doaj_org_article_288765715c1a483491809a088d5bbdb6 10_15421_022040 |
GroupedDBID | AAYXX ABDBF ADBBV ALMA_UNASSIGNED_HOLDINGS BCNDV CITATION GROUPED_DOAJ RIG |
ID | FETCH-LOGICAL-c253t-c5e0038f7b16891b27fafd9d1a4ebf8abe3676549dd22a45a886b09fb3e36f6c3 |
IEDL.DBID | DOA |
ISSN | 2519-8521 |
IngestDate | Thu Jul 04 21:10:30 EDT 2024 Fri Aug 23 01:44:06 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c253t-c5e0038f7b16891b27fafd9d1a4ebf8abe3676549dd22a45a886b09fb3e36f6c3 |
ORCID | 0000-0002-7876-8701 0000-0001-6231-3289 0000-0002-3459-8114 0000-0001-6992-9406 0000-0001-8418-5716 |
OpenAccessLink | https://doaj.org/article/288765715c1a483491809a088d5bbdb6 |
PageCount | 6 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_288765715c1a483491809a088d5bbdb6 crossref_primary_10_15421_022040 |
PublicationCentury | 2000 |
PublicationDate | 2020-01-01 |
PublicationDateYYYYMMDD | 2020-01-01 |
PublicationDate_xml | – month: 01 year: 2020 text: 2020-01-01 day: 01 |
PublicationDecade | 2020 |
PublicationTitle | Regulatory mechanisms in biosystems |
PublicationYear | 2020 |
Publisher | Oles Honchar Dnipro National University |
Publisher_xml | – name: Oles Honchar Dnipro National University |
References | 23207 23218 23208 23219 23209 23199 23210 23200 23211 23201 23212 23202 23213 23203 23214 23204 23215 23205 23216 23206 23217 |
References_xml | – ident: 23216 doi: 10.1111/nure.12089 – ident: 23214 doi: 10.1038/nature09262 – ident: 23215 – ident: 23201 doi: 10.1016/j.stemcr.2018.06.007 – ident: 23213 – ident: 23199 doi: 10.1007/BF02540959 – ident: 23207 – ident: 23202 doi: 10.1515/jcim-2014-0039 – ident: 23206 – ident: 23212 doi: 10.1038/227680a0 – ident: 23211 doi: 10.11648/j.ajbls.s.2014020601.15 – ident: 23208 doi: 10.1002/biof.1339 – ident: 23218 doi: 10.1634/stemcells.22-6-962 – ident: 23219 doi: 10.1073/pnas.1620059114 – ident: 23205 doi: 10.1007/s11515-017-1458-y – ident: 23217 doi: 10.1016/j.micpath.2016.12.007 – ident: 23204 doi: 10.6000/1929-5634.2017.06.04.2 – ident: 23210 doi: 10.1016/j.bbrc.2017.04.011 – ident: 23200 – ident: 23203 doi: 10.6000/1929-5634.2017.06.01.2 – ident: 23209 doi: 10.1016/j.exphem.2004.02.004 |
SSID | ssj0001881717 ssib050737334 |
Score | 2.1366596 |
Snippet | Colostrum is rich in various biologically active compounds such as immunotropic ones. Low molecular weight components were isolated from cow colostrum... |
SourceID | doaj crossref |
SourceType | Open Website Aggregation Database |
StartPage | 272 |
SubjectTerms | morphotypes; oxidative stress; transfer factor; eosinophilia |
Title | Low-molecular weight components of cow colostrum regulate bone marrow functions by modelling the redox-system of the organism |
URI | https://doaj.org/article/288765715c1a483491809a088d5bbdb6 |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA4iCF7EJ64vcvAatk2bNjmquCyinlzYW8kkza27ogvrHvzvziRd6c2LxyYlpDMJ8-jM9zF2C95krVZOmNqCKL2rBHgohdQuKAiZsxEy_-W1ms7Kp7maD6i-qCYswQMnwY0l3oJK1blyuaXElyHAKYt3wyvAVRPYdq4GwRSeJHRyirrogc9itkXrvI70u9SpKTQardRBix6EzMfUbkrpj4FpGiD4R1MzOWQHvY_I79LejthOuzhme4k1cnPCvp-Xa9FtaW35OiY3OdWGLxdUFsGXAZ_WnPCoCR624x-JcL7lgG_wLuIucrJo8dBx2PBIiEOd6RwdQk4gol8igTzTajSW6J8-u1M2mzy-PUxFz6IgnFTFSjjV0u-_UENeaZODrIMN3ngUZwtBW2gJtA3DRO-ltKWyWleQmQAFToTKFWdsd4G7O2e81NRREgwBAqFapTUZWG_IKZFtVsGI8a0Am_cEltFQkEEybpKMR-yeBPs7TejWcQC_oul13vyl84v_WOSS7UuKnWM65Yrtoj7aa3QwVnATz9IPqb3L9Q |
link.rule.ids | 315,786,790,870,2115,27957,27958 |
linkProvider | Directory of Open Access Journals |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Low-molecular+weight+components+of+cow+colostrum+regulate+bone+marrow+functions+by+modelling+the+redox-system+of+the+organism&rft.jtitle=Regulatory+mechanisms+in+biosystems&rft.au=A.+I.+Bozhkov&rft.au=S.+L.+Ohiienko&rft.au=A.+Y.+Bondar&rft.au=E.+G.+Ivanov&rft.date=2020-01-01&rft.pub=Oles+Honchar+Dnipro+National+University&rft.issn=2519-8521&rft.eissn=2520-2588&rft.volume=11&rft.issue=2&rft.spage=272&rft.epage=277&rft_id=info:doi/10.15421%2F022040&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_288765715c1a483491809a088d5bbdb6 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2519-8521&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2519-8521&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2519-8521&client=summon |