Cytokine sensitivity of metastatic human melanoma cell lines-- simultaneous inhibition of proliferation and enhancement of gelatinase activity

• Published in: Pathology oncology research Vol. 4; no. 2; pp. 108 - 114
• Main Authors: Ladányi, A, Nagy, J O, Jeney, A, Tímár, J
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 1998
• Subjects: Animals; Cancer; Cell Division - drug effects; Collagen; Collagenase; Cytokines; Cytokines - pharmacology; Gelatinase; Gelatinases - biosynthesis; Humans; Interleukin-1 - pharmacology; Interleukin-10 - pharmacology; Interleukin-12 - pharmacology; Interleukin-2 - pharmacology; Melanoma; Melanoma - pathology; Metalloproteinase; Metastases; Mice; Mice, Nude; Neoplasm Metastasis; Oncology; Pathology; Proteins; Recombinant Proteins - pharmacology; Skin Neoplasms - pathology; Transforming Growth Factor beta - pharmacology; Transforming growth factor-b; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-α; Tumorigenicity; Tumors

The effect of a panel of cytokines on the proliferation and type IV collagenase production was studied in four melanoma cell lines of different origin, tumorigenicity and metastatic capacity. TGF-b, TNF-a and to a lesser extent, IL-1a exhibited antiproliferative effect on the cell lines, with some l...