Bupivacaine-loaded hydroxypropyl chitin based sponges prepared via a solvent-free process provide long-acting local anesthesia for postoperative pain

• Published in: Journal of drug delivery science and technology Vol. 73; p. 103453
• Main Authors: Yang, Fan, Qiao, Qianqian, Cai, Mingzhen, Xia, Zhongyuan, Jiang, Xulin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2022
• Subjects: Bupivacaine hydrochloride; Hydroxypropyl chitin; Local anesthetics; Postoperative analgesia; Sponge; Sustained release; Hydroxypropyl chitin; Sustained release; Bupivacaine hydrochloride; Sponge; Postoperative analgesia; Local anesthetics

Local anesthetics have been extensively used in clinical practice to relieve the postoperative pain of patients. However, due to the short half-life of local anesthetics, a simple injection of local anesthetics cannot provide sufficient anesthetic effect for patients. It is important to develop a ne...