Interleukin 12 as vaccine adjuvant

• Published in: Research in immunology (Paris) Vol. 149; no. 1; pp. 37 - 39
• Main Authors: Sturmhoefel, K., Lee, K., Toole, M.O, Swiniarski, H.M., Dorner, A.J., Wolf(xc), S.F.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 1998

Interleukin 12 (IL12) is a heterodimeric cytokine with potent immunomodulatory activity in regulating innate and adaptive immune responses. The key to its activity is induction of interferon-gamma (IFN gamma ) from T and NK cells and promotion of T helper progenitors to become T helper type 1 (Th1)...