Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population

• Published in: Annals of human biology Vol. 49; no. 5-6; pp. 260 - 262
• Main Authors: Németh, Stefan, Kriegshäuser, Gernot, Hovhannesyan, Kristine, Hayrapetyan, Hasmik, Oberkanins, Christian, Sarkisian, Tamara
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.09.2022
• Subjects: Adult; allele frequency; Alleles; Armenia; Gene Frequency; Genotype; Humans; hypolactasia; Lactase - genetics; Lactose Intolerance - epidemiology; Lactose Intolerance - genetics; lactose persistence; lct polymorphism; Polymorphism, Single Nucleotide; Armenia; Armenia; lactose persistence; hypolactasia; LCT polymorphism; allele frequency

Primary lactose malabsorption is characterised by a down-regulation of lactase activity after weaning and inability to digest lactose in adulthood. It has been suggested that the historical introduction of dairying led to a positive selection for lactase persistence variants in a regulatory region u...