Association between genetically proxied PPARG activation and psoriasis vulgaris: a Mendelian randomization study

• Published in: The Journal of dermatological treatment Vol. 35; no. 1; p. 2381763
• Main Authors: Xue, Yan, Xia, Yuning, Cheng, Donghao, Shi, Taiyu, Mei, Ping, Hong, Sheng
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.12.2024
• Subjects: Cholesterol, LDL - blood; Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Mendelian randomization study; Pioglitazone - pharmacology; Polymorphism, Single Nucleotide; PPAR gamma - agonists; PPAR gamma - genetics; PPARG; Psoriasis - drug therapy; Psoriasis - genetics; Psoriasis - pathology; psoriasis vulgaris; psoriasis vulgaris; PPARG; Mendelian randomization study

Psoriasis is a common autoimmune disease in clinical practice, and previous observational studies have suggested that PPARG agonists such as Pioglitazone may be potential therapeutic agents. However, due to interference from various confounding factors, different observational studies have not reach...