Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

• Published in: Science translational medicine Vol. 8; no. 334; p. 334ra54
• Main Authors: Ribas, Vicent, Drew, Brian G, Zhou, Zhenqi, Phun, Jennifer, Kalajian, Nareg Y, Soleymani, Teo, Daraei, Pedram, Widjaja, Kevin, Wanagat, Jonathan, de Aguiar Vallim, Thomas Q, Fluitt, Amy H, Bensinger, Steven, Le, Thuc, Radu, Caius, Whitelegge, Julian P, Beaven, Simon W, Tontonoz, Peter, Lusis, Aldons J, Parks, Brian W, Vergnes, Laurent, Reue, Karen, Singh, Harpreet, Bopassa, Jean C, Toro, Ligia, Stefani, Enrico, Watt, Matthew J, Schenk, Simon, Akerstrom, Thorbjorn, Kelly, Meghan, Pedersen, Bente K, Hewitt, Sylvia C, Korach, Kenneth S, Hevener, Andrea L
• Format: Journal Article
• Language: English
• Published: United States 13.04.2016
• Subjects: Animals; Autophagy - drug effects; Calcium-Binding Proteins; DNA Replication - drug effects; DNA, Mitochondrial - genetics; Dynamins - metabolism; Estrogen Receptor alpha - metabolism; Female; Gene Deletion; Glucose - metabolism; Homeostasis - drug effects; Humans; Insulin - pharmacology; Intracellular Signaling Peptides and Proteins - metabolism; Lipid Metabolism - drug effects; Mice; Mice, Knockout; Mitochondria, Muscle - drug effects; Mitochondria, Muscle - metabolism; Mitochondrial Dynamics - drug effects; Muscle Proteins - metabolism; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Organ Specificity - drug effects; Oxidation-Reduction - drug effects; Oxidative Stress - drug effects; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects

Impaired estrogen receptor α (ERα) action promotes obesity and metabolic dysfunction in humans and mice; however, the mechanisms underlying these phenotypes remain unknown. Considering that skeletal muscle is a primary tissue responsible for glucose disposal and oxidative metabolism, we established...