NK cell activation and CD4+ T cell α4β7 expression are associated with susceptibility to HIV-1

• Published in: The Journal of clinical investigation Vol. 135; no. 15
• Main Authors: Machmach, Kawthar, N’guessan, Kombo F., Farmer, Rohit, Godbole, Sucheta, Kim, Dohoon, McCormick, Lauren, Lima, Noemia S., Henry, Amy R., Laboune, Farida, Swafford, Isabella, Mika, Sydney K., Slike, Bonnie M., Currier, Jeffrey R., Eller, Leigh Anne, Ake, Julie A., Vasan, Sandhya, Robb, Merlin L., Krebs, Shelly J., Douek, Daniel C., Paquin-Proulx, Dominic
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.08.2025
• Subjects: Adult; CD4-Positive T-Lymphocytes - immunology; Disease Susceptibility; Female; HIV Infections - immunology; HIV-1 - immunology; Humans; Integrins; Killer Cells, Natural - immunology; Killer Cells, Natural - pathology; Lymphocyte Activation - immunology; Male; Middle Aged; Natural Killer T-Cells - immunology; Natural Killer T-Cells - pathology; Prospective Studies; Infectious disease; AIDS/HIV; NK cells; NKT cells; T cells

We leveraged specimens from the RV217 prospective study that enrolled participants at high risk of HIV-1 acquisition to investigate how NK cells, conventional T cells, and unconventional T cells influence HIV-1 acquisition. We observed low levels of α4β7 expression on memory CD4+ T cells and invaria...