Is therapeutic plasma exchange effective in leptospirosis-associated severe pulmonary haemorrhagic syndrome? A systematic review

• Published in: Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 119; no. 5; pp. 453 - 463
• Main Authors: Bandara, J M R P, Rosairo, A, Ranasinghe, G S, De Silva, T D, Gawarammana, I B
• Format: Journal Article
• Language: English
• Published: England 01.05.2025
• Subjects: Hemorrhage - etiology; Hemorrhage - therapy; Humans; Leptospirosis - complications; Leptospirosis - therapy; Lung Diseases - etiology; Lung Diseases - microbiology; Lung Diseases - therapy; Plasma Exchange - methods; Treatment Outcome; leptospirosis; lung disease; plasma exchange; plasmapheresis

Leptospirosis is a re-emerging zoonosis fast becoming a global burden. Pulmonary haemorrhages are a deadly complication, with case fatality rates >50%. Systemic vasculitis is thought to be the pathological process responsible for pulmonary haemorrhages and therapeutic plasma exchange (TPE) is one...