Transcriptional regulation of indoleamine 2,3-dioxygenase (IDO) by tryptophan and its analogue : Down-regulation of the indoleamine 2,3-dioxygenase (IDO) transcription by tryptophan and its analogue

• Published in: Cytotechnology (Dordrecht) Vol. 54; no. 2; pp. 107 - 113
• Main Authors: OKAMOTO, Takeaki, TONE, Shigenobu, KANOUCHI, Hiroaki, MIYAWAKI, Chie, ONO, Sayuri, MINATOGAWA, Yohsuke
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.06.2007; Kluwer Academic Publishers
• Subjects: Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Original Research; Regulation(control); Transcription; Enzyme; Analog; Tryptophan; 1-Methyl-L- tryptophan, Methylthiohydantoin-DL-tryptophan; Indoleamine-pyrrole 2,3-dioxygenase; Oxidoreductases; CMT-93· IFN-γ

Indoleamine 2,3-dioxygenase (IDO; EC 1.13.11.42) is a rate-limiting enzyme involved in the catabolism of tryptophan, which is an essential amino acid. It is induced under pathological conditions, such as the presence of viral infections or tumour cells. This enzyme is induced by IFN-gamma in the mou...