Multifunctional Beta‐ Cyclodextrin‐Modified Selenium Hybrid Hollow Mesoporous Silica Nanospheres for Mitochondrial Targeted Carbon Monoxide Delivery

• Published in: Small (Weinheim an der Bergstrasse, Germany) p. e04264
• Main Authors: Zhou, Junyi, Lian, Yating, Wang, Hanzhang, Lu, Bin, Zheng, Xue, Lai, Jieying, Wang, Fen, Guo, Shuang‐Zhuang, Zhang, Li‐Ming
• Format: Journal Article
• Language: English
• Published: Germany 22.07.2025
• Subjects: carbon monoxide; gas therapy; apoptosis; mitochondrial damage

Carbon monoxide (CO) gas therapy has recently emerged as a promising strategy for cancer treatment. However, the uncontrolled release of CO and challenges in accumulating it at tumor sites have limited its therapeutic efficacy. In this work, a stepwise targeted delivery and a controlled release stra...