Sex Differences in Insulin-Induced Hippocampus Functional Connectivity During Visual Food-Cue Presentation

• Published in: The journal of clinical endocrinology and metabolism Vol. 110; no. 8; p. e2631
• Main Authors: Zhao, Sixiu, Veit, Ralf, Semeia, Lorenzo, Hummel, Julia, Sandforth, Leontine, Fritsche, Andreas, Birkenfeld, Andreas L, Heni, Martin, Preissl, Hubert, Kullmann, Stephanie
• Format: Journal Article
• Language: English
• Published: United States 01.08.2025
• Subjects: Administration, Intranasal; Adult; Aged; Craving - drug effects; Cues; Estradiol - blood; Female; Food; Hippocampus - diagnostic imaging; Hippocampus - drug effects; Hippocampus - physiology; Humans; Insulin - administration & dosage; Insulin - pharmacology; Magnetic Resonance Imaging; Male; Middle Aged; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - drug effects; Prefrontal Cortex - physiology; Progesterone - blood; Sex Characteristics; Young Adult; fMRI; hippocampus; insulin; sex

Central insulin has been shown to regulate eating behavior and cognitive processes in a sex-specific manner. Besides memory, the hippocampus is pivotal in the control of appetite. This work aimed to investigate how insulin interacts with the hippocampal food-cue response and evaluate the potential r...