T-lymphocyte production of macrophage inflammatory protein-1α is critical to the recruitment of CD8+ T cells to the liver, lung, and spleen during graft-versus-host disease

• Published in: Blood Vol. 96; no. 9; pp. 2973 - 2980
• Main Authors: Serody, Jonathan S., Burkett, Susan E., Panoskaltsis-Mortari, Angela, Ng-Cashin, Judith, McMahon, Eileen, Matsushima, Glenn K., Lira, Sergio A., Cook, Donald N., Blazar, Bruce R.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.11.2000; The Americain Society of Hematology
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone marrow, stem cells transplantation. Graft versus host reaction; Medical sciences; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Immunopathology; Animal model; Immune response; Stem cell; Rodentia; Hematopoietic cell; Homograft; Graft versus host reaction; Macrophage inflammatory protein 1alpha; Cell subpopulation; Chemokine; Vertebrata; Mammalia; Donor; Mouse; Animal; T-Lymphocyte; Graft; Suppressive cell

To investigate the mechanism by which macrophage inflammatory protein-1α (MIP-1α) affects graft-versus-host disease (GVHD), the expression and function of MIP-1α in 2 murine models of GVHD were evaluated. In irradiated class I and class II disparate recipients, the expression of messenger RNA (mRNA)...