Investigation of absorption, metabolism, and excretion of [14C]pruxelutamide (GT0918), an androgen receptor antagonist in humans - Zheng, Yuan‐dong; Ma, Sheng; Yuan, Ya‐li; Zhang, Hua; Yang, Ying; Ye, Feng‐zhi; Wang, Mei‐yu; Chen, Jie; Tong, You‐zhi; Hu, Tao; He, Yi‐fei; Zhang, Yi‐fan; et al. (British journal of clinical pharmacology, 2025)
Keywords: [14C]pruxelutamide (GT0918); Administration, Oral; Adult; aldehyde metabolism intermediate; Androgen Receptor Antagonists - administration & dosage; Androgen Receptor Antagonists - blood; Androgen Receptor Antagonists - pharmacokinetics; Androgen Receptor Antagonists - urine; AR antagonist; Biotransformation; Carbon Radioisotopes; COVID‐19 treatment; Cytochrome P-450 CYP3A - metabolism; Feces - chemistry; Healthy Volunteers; Humans; Male; mass balance; oxazole ring metabolism; Pyrazoles - pharmacokinetics; Pyrazoles - urine; Young Adult; oxazole ring metabolism; AR antagonist; COVID‐19 treatment; mass balance; [14C]pruxelutamide (GT0918); aldehyde metabolism intermediate