Long-term suppression of lymphangitic lung metastasis from breast cancer using biweekly docetaxel: a case report

• Published in: Breast cancer (Tokyo, Japan) Vol. 10; no. 4; pp. 361 - 365
• Main Authors: Ninomiya, Jun, Horiguchi, Jun, Koibuchi, Yukio, Yoshida, Takashi, Iijima, Kotaro, Yoshida, Miho, Takata, Daisuke, Yokoe, Takao, Iino, Yuichi, Morishita, Yasuo
• Format: Journal Article
• Language: English
• Published: Japan 01.10.2003
• Subjects: Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - therapeutic use; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Drug Administration Schedule; Female; Humans; Lung Neoplasms - prevention & control; Lung Neoplasms - secondary; Lymphatic Metastasis; Middle Aged; Taxoids - administration & dosage; Taxoids - therapeutic use; Tomography, X-Ray Computed
• ISSN: 1340-6868; 1880-4233
• DOI: 10.1007/BF02967658

A 45-year-old woman underwent a modified radical mastectomy for right breast cancer in July 1996. As lymph node metastases were quite advanced, chemotherapy was started with anthracyclines. Four years after surgery, cough and dyspnea appeared. Chest radiograph and CT showed reticular shadows bilaterally and slight pleural effusion, suggesting lymphangitic lung metastasis of breast cancer. Biweekly intravenous docetaxel (TXT,45 mg/m2) was initiated. Four courses of TXT ameliorated her complaints and radiographic findings. A total of 30 continuous courses of TXT suppressed disease exacerbation for 18 months until new lesions manifested in January 2002. The main side effects were grade 2 leukopenia and alopecia. This case report describes a patient with long-term suppression of lymphangitic lung metastasis of breast cancer using biweekly TXT without severe side effects or worsening quality of life.