Synthesis & characterization of N-amino-glyphosate as a potent analog inhibitor of E. coli EPSP synthase

All previous attempts to identify glyphosate analogs which retain their potency against the known biological target, EPSP synthase, have been unsuccessful. Consequently, the glyphosate binding site was thought to be extremely specific in this system. Here we report the novel N-amino glyphosate analo...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 3; no. 12; pp. 2863 - 2868
Main Authors Knowles, William S., Anderson, Karen S., Andrew, Steven S., Phillion, Dennis P., Ream, Joel E., Johnson, Kenneth A., Sikorski, James A.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 1993
Elsevier
Subjects
Biological and medical sciences
Medical sciences
Pesticides, fertilizers and other agrochemicals toxicology
Toxicology
Structure activity relation
Enzyme
Transferases
Analog
Escherichia coli
Pesticides
Enzyme inhibitor
Bacteria
Chemical synthesis
3-Phosphoshikimate 1-carboxyvinyltransferase
Herbicide
Enterobacteriaceae
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Summary:All previous attempts to identify glyphosate analogs which retain their potency against the known biological target, EPSP synthase, have been unsuccessful. Consequently, the glyphosate binding site was thought to be extremely specific in this system. Here we report the novel N-amino glyphosate analog 3 as the first successful modification of the glyphosate skeleton which exhibits inhibitor properties comparable to glyphosate. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80780-0