Pseudotargeted metabolomics method and its application in erastin-stimulated gastric adenocarcinoma cells based on liquid chromatography with tandem mass spectrometry

• Published in: International journal of mass spectrometry Vol. 500; p. 117238
• Main Authors: Liu, Ying, Hu, Wenchao, Asmamaw, Mogesdessale, Pan, Lulu, Liu, Hongmin, Li, Juan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2024
• Subjects: Erastin; Gastric cancer; LC-MS/MS; Metabolomics; MGC-803 cells; Pseudotargeted method; Pseudotargeted method; Metabolomics; LC-MS/MS; Erastin; MGC-803 cells; Gastric cancer

Erastin, a classical ferroptosis inducer, exerts cytotoxicity in several types of cancer cells including gastric cancer cells. However, the mechanism of erastin in regulating metabolic pathways in gastric cancer remains largely unclear. To investigate the gastric cellular response to erastin therapy...