Multi-level ROS regulation to activate innate and adaptive immune therapies

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 515; p. 163429
• Main Authors: Feng, Ke-Ke, Li, Cheng-Lei, Tu, Yi-Fan, Tian, Shi-Cheng, Xiong, Rui, Sa, Bai-Sheng, Shao, Jing-Wei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2025
• Subjects: Adaptive immunity; cGAS/STING; CRISPR/Cas9; MXene; Theranostics; Tumor immune microenvironment; Tumor immune microenvironment; Adaptive immunity; CRISPR/Cas9; Theranostics; MXene; cGAS/STING

•VGRM integrated GOx and CRISPR/Cas9 on 2D vanadium carbide MXene for enhanced ROS and immune activation.•VGRM amplified ROS production and depleted GSH via cascade reaction, enhancing tumor cell damage.•VGRM activated cGAS/STING pathway, induced ICD, promoted CD8+ T cell infiltration, and reversed...