Transition-metal-free, direct C-H radical trifluoromethylation of nitroimidazoles with Togni's reagent
Trifluoromethyl moiety in bioactive compounds can dramatically change both the physicochemical and physiological properties, which could further improve both the pharmacokinetic and pharmacological profiles. It has therefore become indispensable to develop an efficient and mild synthetic methodology...
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Published in | Tetrahedron letters Vol. 92; pp. 153659 - 153665 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
02.03.2022
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Subjects | |
Online Access | Get full text |
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