Increased Platelet Inhibition After Switching From Maintenance Clopidogrel to Prasugrel in Patients With Acute Coronary Syndromes

• Published in: Journal of the American College of Cardiology Vol. 56; no. 13; pp. 1017 - 1023
• Main Authors: Angiolillo, Dominick J., Saucedo, Jorge F., DeRaad, Roger, Frelinger, Andrew L., Gurbel, Paul A., Costigan, Timothy M., Jakubowski, Joseph A., Ojeh, Clement K., Effron, Mark B.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 21.09.2010
• Subjects: acute coronary syndrome; Cardiovascular; clopidogrel; Internal Medicine; platelet; prasugrel; clopidogrel; prasugrel; ADP; VASP-P; ACS; PRU; acute coronary syndrome; MD; PCI; LD; LTA; VN; platelet; MPA; VerifyNow; P2Y 12 reaction units; maintenance dose; loading dose; vasodilator-stimulated phosphoprotein phosphorylation; light transmittance aggregometry; percutaneous coronary intervention; maximum platelet aggregation; adenosine diphosphate

The objective was to evaluate the pharmacodynamic response of switching patients on maintenance phase clopidogrel therapy after an acute coronary syndrome (ACS) to prasugrel. Prasugrel P2Y12 receptor blockade is associated with greater pharmacodynamic platelet inhibition and reduction of ischemic co...