4-[ 123I]Iodospiperone as a ligand for dopamine DA receptors: In vitro and in vivo experiments in a rat model

• Published in: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Vol. 19; no. 7; pp. 759 - 763
• Main Authors: Van Der Krogt, J.A., Pauwels, E.K.J., Van Doremalen, P.A.P.M., Wijnhoven, G., Reiffers, S., Van Valkenburg, C.F.M., Buruma, O.J.S.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.10.1992; Pergamon
• Subjects: Animals; Binding, Competitive; Biological and medical sciences; Brain - metabolism; Cell Membrane - metabolism; Contrast media. Radiopharmaceuticals; Corpus Striatum - metabolism; Iodine Radioisotopes; Male; Medical sciences; Organ Specificity; Pharmacology. Drug treatments; Rats; Rats, Wistar; Receptors, Dopamine - analysis; Receptors, Dopamine - metabolism; Spiperone - analogs & derivatives; Spiperone - metabolism; Tritium; In vivo; Dopamine; Ligand; Dopamine receptor; Animal; Brain (invertebrata); Exploration; In vitro; Positron emission tomography

Radioiodinated spiperone is of interest for dopamine (DA) receptor studies in the living human brain by single photon emission computed tomography (SPECT). Stimulated by data obtained with [ 11C]- N-methyl-spiperone we synthesized 4-[ 123I]iodospiperone and investigated the in vitro binding characte...