Phospholipase A2 expression in tumours: a target for therapeutic intervention?

• Published in: Drug discovery today Vol. 8; no. 15; pp. 710 - 716
• Main Authors: Laye, Jonathan P, Gill, Jason H
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Science 01.08.2003
• Subjects: Animals; Biological and medical sciences; Calcium - physiology; Cytosol - enzymology; Drug Delivery Systems - methods; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Medical sciences; Neoplasms - drug therapy; Neoplasms - enzymology; Phospholipases A - biosynthesis; Phospholipases A - genetics; Phospholipases A - physiology; Phospholipases A - secretion; Phospholipases A2

Phospholipase A(2) (PLA(2)) enzymes are involved in lipid metabolism and, as such, are central to several cellular processes. The different PLA(2)s identified to date can be classified into three groups: secreted PLA(2) (sPLA(2)), calcium-independent PLA(2) (iPLA(2)) and calcium-dependent cytosolic...