Evaluation of the hypothalamic-pituitary-adrenal axis in children with leukemia before and after 6 weeks of high-dose glucocorticoid therapy

• Published in: The journal of clinical endocrinology and metabolism Vol. 86; no. 7; pp. 2993 - 2996
• Main Authors: KUPERMAN, Hilton, DAMIANI, Durval, CHROUSOS, George P, DICHTCHEKENIAN, Vaê, DELLA MANNA, Thais, ODONE, Vicente FILHO, SETIAN, Nuvarte
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.07.2001
• Subjects: Adrenal Glands - drug effects; Adrenal Glands - physiopathology; Adrenal Insufficiency - chemically induced; Adrenocorticotropic Hormone - blood; Biological and medical sciences; Child; Child, Preschool; Corticotropin-Releasing Hormone; Dexamethasone - administration & dosage; Dexamethasone - adverse effects; Dexamethasone - therapeutic use; Drug toxicity and drugs side effects treatment; Female; Glucocorticoids - administration & dosage; Glucocorticoids - adverse effects; Glucocorticoids - therapeutic use; Humans; Hydrocortisone - blood; Hypothalamus - drug effects; Hypothalamus - physiopathology; Infant; Kinetics; Male; Medical sciences; Miscellaneous (drug allergy, mutagens, teratogens...); Pharmacology. Drug treatments; Pituitary Gland - drug effects; Pituitary Gland - physiopathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology; Endocrinopathy; Human; Corticosteroid; Hypothalamohypophysoadrenal axis disorders; Dexamethasone; Toxicity; Acute; Infant; Malignant hemopathy; Chronic lymphocytic leukemia; Adrenal insufficiency; Lymphoproliferative syndrome; Adrenal gland diseases; Hormonal investigation; High dose; Child

Among the adverse effects arising from chronic high-dose glucocorticoid treatment, adrenal insufficiency secondary to suppression of the hypothalamic-pituitary-adrenal (HPA) axis is a cause for concern. Glucocorticoid-induced adrenal suppression is related to the duration of therapy, type of steroid...