Synthesis and biological evaluation of aryl amide derivatives of pyridine-imidazo[1,2-a]pyrazine-oxazole as anticancer agents

A new series of aryl amide derivatives of pyridine-imidazo[1,2-a]pyrazine-oxazoles (15a-j) has been designed, synthesized and screened for their anticancer activity against MCF-7 (human breast cancer), A549 (human lung cancer), Colo-205 (human colon cancer) and A2780 (human ovarian cancer) cell line...

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Bibliographic Details
Published inChemical Data Collections Vol. 55; p. 101176
Main Authors Vanam, Narendhar Reddy, Gadipelli, Prakash, Anireddy, Jaya Shree
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.02.2025
Subjects
1,3-oxazole and anticancer activity
Coelenterazine
Imidazo[1,2-a]pyrazine
Mubritinib
Mubritinib
Imidazo[1,2-a]pyrazine
Coelenterazine
1,3-oxazole and anticancer activity
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Summary:A new series of aryl amide derivatives of pyridine-imidazo[1,2-a]pyrazine-oxazoles (15a-j) has been designed, synthesized and screened for their anticancer activity against MCF-7 (human breast cancer), A549 (human lung cancer), Colo-205 (human colon cancer) and A2780 (human ovarian cancer) cell lines by using MTT reduction assay protocol with etoposide (Etoposide) as standard drug. Among the synthesized derivatives, the compound 15a with trimethoxy electron donating substituent showed potent anticancer activity against MCF-7, A549, Colo-205, and A2780 cell lines with IC50 values of 0.03 ± 0.0043 µM; 0.02 ± 0.0077 µM; 0.12 ± 0.066 µM; and 0.17 ± 0.059 µM respectively. [Display omitted]
ISSN:2405-8300
2405-8300
DOI:10.1016/j.cdc.2024.101176