Site-specific splice variation of the human P2X4 receptor

• Published in: Neuroscience letters Vol. 273; no. 3; pp. 183 - 186
• Main Authors: CARPENTER, D, MEADOWS, H. J, RICE, S. Q. J, TOMLINSON, W. J, WOOD, M, SANGER, G. J, BROUGH, S, CHAPMAN, G, CLARKE, C, COLDWELL, M, DAVIS, R, HARRISON, D, MEAKIN, J, MCHALE, M
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier 08.10.1999
• Subjects: Adenosine Triphosphate - pharmacology; Adenosinic and purinergic receptors; Alternative Splicing - drug effects; Alternative Splicing - genetics; Amino Acid Sequence - genetics; Animals; Biological and medical sciences; Cell receptors; Cell structures and functions; Cells, Cultured; DNA - genetics; Fundamental and applied biological sciences. Psychology; Humans; Molecular and cellular biology; Molecular Sequence Data; Neuropeptides - drug effects; Neuropeptides - genetics; Neuropeptides - metabolism; Oocytes; Receptors, Purinergic P2 - drug effects; Receptors, Purinergic P2 - genetics; Receptors, Purinergic P2 - metabolism; Receptors, Purinergic P2X4; Transfection - genetics; Xenopus; Human; P2 Purinergic receptor; Alternative splicing; Subunit; Genetic variant

P2X4 receptors are expressed in specific brain areas. We now describe site-specific splice variations of the human P2X4 receptor subunit, occurring at residue [YVIG / WVFV(W)] near the end of the first predicted transmembrane domain. p2X4(b) is formed by the insertion of an additional 16 amino acids...