The neuroprotective effects of progesterone on experimental diabetic neuropathy in rats

• Published in: Pakistan journal of biological sciences Vol. 11; no. 16; pp. 1994 - 2000
• Main Authors: Sameni, H R, Panahi, M, Sarkaki, A, Saki, G H, Makvandi, M
• Format: Journal Article
• Language: English
• Published: Pakistan 15.08.2008
• Subjects: Animals; Blood Glucose - metabolism; Body Weight - drug effects; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - pathology; Diabetic Neuropathies - chemically induced; Diabetic Neuropathies - complications; Diabetic Neuropathies - drug therapy; Diabetic Neuropathies - pathology; Electrophysiology; Male; Neuroprotective Agents - therapeutic use; Progesterone - therapeutic use; Rats; Rats, Sprague-Dawley; Streptozocin - pharmacology; Pakistan

This study was conducted to investigate the neuroprotective effects of progesterone (PROG) on electrophysiological and histomorphometrical alternation in STZ-induced diabetic neuropathy starting from 4 weeks after the diabetic induction. Thirty adult male Sprague-Dawley rats were randomly divided in...