Free radical theory of aging: an update: increasing the functional life span

• Published in: Annals of the New York Academy of Sciences Vol. 1067; no. 1; pp. 10 - 21
• Main Author: Harman, Denham
• Format: Journal Article
• Language: English
• Published: United States 01.05.2006
• Subjects: Aging - physiology; Biological Evolution; Free Radicals - metabolism; Humans; Life Expectancy - trends; Longevity - physiology; Models, Biological; Mortality - trends

Aging is the progressive accumulation of diverse, deleterious changes with time that increase the chance of disease and death. The basic chemical process underlying aging was first advanced by the free radical theory of aging (FRTA) in 1954: the reaction of active free radicals, normally produced in...