Free radical theory of aging: an update: increasing the functional life span

Aging is the progressive accumulation of diverse, deleterious changes with time that increase the chance of disease and death. The basic chemical process underlying aging was first advanced by the free radical theory of aging (FRTA) in 1954: the reaction of active free radicals, normally produced in...

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Published inAnnals of the New York Academy of Sciences Vol. 1067; no. 1; pp. 10 - 21
Main Author Harman, Denham
Format Journal Article
LanguageEnglish
Published United States 01.05.2006
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Abstract Aging is the progressive accumulation of diverse, deleterious changes with time that increase the chance of disease and death. The basic chemical process underlying aging was first advanced by the free radical theory of aging (FRTA) in 1954: the reaction of active free radicals, normally produced in the organisms, with cellular constituents initiates the changes associated with aging. The involvement of free radicals in aging is related to their key role in the origin and evolution of life. Aging changes are commonly attributed to development, genetic defects, the environment, disease, and an inborn aging process (IAP). The latter produces aging changes at an exponentially increasing rate with age, becoming the major risk factor for disease and death for humans after the age of 28 years in the developed countries. In them the IAP limits human average life expectancy at birth (ALE-B)--a rough measure of the healthy life span--to about 85 years; few reach 100 years and only one is known to have lived to 122 years. In these countries, improvements in living conditions (ILC) have gradually raised ALE-Bs to 76-79 years, 6-9 years less than the limit imposed by aging, with no change in the maximum life span (MLS). The extensive studies based on the FRTA hold promise that ALE-B and the MLS can be extended, the ALE-B possibly by a few years, and the MLS somewhat less.
AbstractList Aging is the progressive accumulation of diverse, deleterious changes with time that increase the chance of disease and death. The basic chemical process underlying aging was first advanced by the free radical theory of aging (FRTA) in 1954: the reaction of active free radicals, normally produced in the organisms, with cellular constituents initiates the changes associated with aging. The involvement of free radicals in aging is related to their key role in the origin and evolution of life. Aging changes are commonly attributed to development, genetic defects, the environment, disease, and an inborn aging process (IAP). The latter produces aging changes at an exponentially increasing rate with age, becoming the major risk factor for disease and death for humans after the age of 28 years in the developed countries. In them the IAP limits human average life expectancy at birth (ALE-B)--a rough measure of the healthy life span--to about 85 years; few reach 100 years and only one is known to have lived to 122 years. In these countries, improvements in living conditions (ILC) have gradually raised ALE-Bs to 76-79 years, 6-9 years less than the limit imposed by aging, with no change in the maximum life span (MLS). The extensive studies based on the FRTA hold promise that ALE-B and the MLS can be extended, the ALE-B possibly by a few years, and the MLS somewhat less.
Author Harman, Denham
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Cites_doi 10.1089/109454503769684793
10.1111/j.1532-5415.1972.tb00787.x
10.1111/j.1749-6632.2001.tb05631.x
10.1073/pnas.74.2.570
10.1196/annals.1297.073
10.1093/geronj/12.3.306
10.1016/S0021-9258(17)36891-6
10.1016/0531-5565(79)90039-1
10.1007/BF02432509
10.1023/A:1005427919188
10.1089/109454503322733081
10.1038/nature02517
10.1001/archsurg.1994.01420360030003
10.2165/00002512-199303010-00006
10.1086/402632
10.1016/S0014-2999(99)00910-3
10.1073/pnas.95.15.8892
10.1016/0891-5849(93)90165-Q
10.1007/BF02432519
10.1038/sj.onc.1205513
10.1093/geronj/11.3.298
10.1126/science.283.5407.1482
10.3109/10715769409056584
10.1016/S0140-6736(05)78211-8
10.1007/BF02435819
10.1016/0047-6374(93)90132-B
10.1016/S0140-6736(97)07382-0
10.1073/pnas.96.22.12216
10.1089/152308603770310202
10.1093/ajcn/63.5.760
10.1006/bbrc.1993.2208
10.1126/science.283.5407.1476
10.1111/j.1749-6632.2002.tb02109.x
10.1126/science.1112125
10.1038/nature01629
10.1007/978-3-0348-7460-1_1
10.1007/BF02540904
10.1111/j.1749-6632.2002.tb02098.x
10.2307/3571274
10.1016/S0140-6736(05)61126-9
10.1073/pnas.78.11.7124
10.1096/fasebj.10.2.8641567
10.1016/S0960-9822(02)00808-4
10.1056/NEJMra021333
10.1001/jama.289.19.2481
10.1016/0047-6374(94)90104-X
10.1023/B:BGEN.0000006561.15498.68
10.1126/science.1106653
10.1073/pnas.261708898
10.1089/rej.1.1999.2.199
10.1016/j.toxlet.2003.12.017
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References e_1_2_3_50_2
Peterson P. (e_1_2_3_64_2) 1999
National Center for Health Statistics (e_1_2_3_7_2) 1988
Jones H.R. (e_1_2_3_5_2) 1955
Harman D. (e_1_2_3_4_2) 2000; 23
e_1_2_3_16_2
e_1_2_3_18_2
e_1_2_3_39_2
e_1_2_3_56_2
e_1_2_3_8_2
e_1_2_3_12_2
e_1_2_3_33_2
e_1_2_3_58_2
e_1_2_3_52_2
e_1_2_3_54_2
e_1_2_3_10_2
e_1_2_3_31_2
e_1_2_3_60_2
Oparin A.I. (e_1_2_3_35_2) 1953
Sveriges Officiella Statistik (e_1_2_3_6_2) 1992
Day W. (e_1_2_3_37_2) 1979
e_1_2_3_26_2
e_1_2_3_49_2
e_1_2_3_28_2
Lundberg W.O. (e_1_2_3_42_2) 1962
Kohn R.R. (e_1_2_3_2_2) 1985
e_1_2_3_22_2
e_1_2_3_45_2
e_1_2_3_24_2
e_1_2_3_47_2
e_1_2_3_41_2
e_1_2_3_20_2
e_1_2_3_43_2
e_1_2_3_62_2
e_1_2_3_19_2
Miller S.L. (e_1_2_3_36_2) 1959
e_1_2_3_15_2
e_1_2_3_38_2
e_1_2_3_3_2
e_1_2_3_17_2
e_1_2_3_59_2
e_1_2_3_9_2
e_1_2_3_11_2
e_1_2_3_34_2
e_1_2_3_55_2
e_1_2_3_13_2
e_1_2_3_57_2
e_1_2_3_30_2
e_1_2_3_51_2
e_1_2_3_32_2
e_1_2_3_53_2
e_1_2_3_61_2
e_1_2_3_27_2
e_1_2_3_48_2
e_1_2_3_29_2
Harman D. (e_1_2_3_14_2) 2000; 23
e_1_2_3_23_2
e_1_2_3_44_2
e_1_2_3_25_2
e_1_2_3_46_2
e_1_2_3_40_2
e_1_2_3_21_2
e_1_2_3_63_2
References_xml – ident: e_1_2_3_61_2
  doi: 10.1089/109454503769684793
– ident: e_1_2_3_11_2
  doi: 10.1111/j.1532-5415.1972.tb00787.x
– ident: e_1_2_3_63_2
  doi: 10.1111/j.1749-6632.2001.tb05631.x
– ident: e_1_2_3_49_2
  doi: 10.1073/pnas.74.2.570
– ident: e_1_2_3_56_2
  doi: 10.1196/annals.1297.073
– start-page: 123
  volume-title: The Origin of Life
  year: 1959
  ident: e_1_2_3_36_2
  contributor:
    fullname: Miller S.L.
– ident: e_1_2_3_44_2
  doi: 10.1093/geronj/12.3.306
– ident: e_1_2_3_53_2
  doi: 10.1016/S0021-9258(17)36891-6
– start-page: 114
  volume-title: Statistiska centralbyran
  year: 1992
  ident: e_1_2_3_6_2
  contributor:
    fullname: Sveriges Officiella Statistik
– ident: e_1_2_3_54_2
  doi: 10.1016/0531-5565(79)90039-1
– ident: e_1_2_3_12_2
  doi: 10.1007/BF02432509
– ident: e_1_2_3_40_2
  doi: 10.1023/A:1005427919188
– ident: e_1_2_3_62_2
  doi: 10.1089/109454503322733081
– ident: e_1_2_3_21_2
  doi: 10.1038/nature02517
– ident: e_1_2_3_17_2
  doi: 10.1001/archsurg.1994.01420360030003
– volume-title: Life Tables, Vol. 2 (6)
  year: 1988
  ident: e_1_2_3_7_2
  contributor:
    fullname: National Center for Health Statistics
– start-page: 31
  volume-title: Lipids and Their Oxidation
  year: 1962
  ident: e_1_2_3_42_2
  contributor:
    fullname: Lundberg W.O.
– ident: e_1_2_3_30_2
  doi: 10.2165/00002512-199303010-00006
– ident: e_1_2_3_46_2
  doi: 10.1086/402632
– ident: e_1_2_3_18_2
  doi: 10.1016/S0014-2999(99)00910-3
– ident: e_1_2_3_50_2
  doi: 10.1073/pnas.95.15.8892
– ident: e_1_2_3_26_2
  doi: 10.1016/0891-5849(93)90165-Q
– start-page: 1
  volume-title: Relation between Normal Aging and Disease
  year: 1985
  ident: e_1_2_3_2_2
  contributor:
    fullname: Kohn R.R.
– ident: e_1_2_3_32_2
  doi: 10.1007/BF02432519
– ident: e_1_2_3_57_2
  doi: 10.1038/sj.onc.1205513
– ident: e_1_2_3_8_2
  doi: 10.1093/geronj/11.3.298
– ident: e_1_2_3_39_2
  doi: 10.1126/science.283.5407.1482
– volume: 23
  start-page: 25
  year: 2000
  ident: e_1_2_3_4_2
  article-title: Antioxidant supplements: effect on disease and aging in the United States population
  publication-title: J. Am. Aging Assoc
  contributor:
    fullname: Harman D.
– start-page: 160
  volume-title: Gray Dawn
  year: 1999
  ident: e_1_2_3_64_2
  contributor:
    fullname: Peterson P.
– ident: e_1_2_3_24_2
  doi: 10.3109/10715769409056584
– ident: e_1_2_3_27_2
  doi: 10.1016/S0140-6736(05)78211-8
– ident: e_1_2_3_3_2
  doi: 10.1007/BF02435819
– ident: e_1_2_3_23_2
  doi: 10.1016/0047-6374(93)90132-B
– ident: e_1_2_3_45_2
– ident: e_1_2_3_19_2
  doi: 10.1016/S0140-6736(97)07382-0
– ident: e_1_2_3_33_2
  doi: 10.1073/pnas.96.22.12216
– ident: e_1_2_3_58_2
  doi: 10.1089/152308603770310202
– ident: e_1_2_3_15_2
  doi: 10.1093/ajcn/63.5.760
– ident: e_1_2_3_25_2
  doi: 10.1006/bbrc.1993.2208
– ident: e_1_2_3_38_2
  doi: 10.1126/science.283.5407.1476
– volume-title: Genesis on Planet Earth
  year: 1979
  ident: e_1_2_3_37_2
  contributor:
    fullname: Day W.
– ident: e_1_2_3_20_2
  doi: 10.1111/j.1749-6632.2002.tb02109.x
– volume-title: Origin of Life
  year: 1953
  ident: e_1_2_3_35_2
  contributor:
    fullname: Oparin A.I.
– ident: e_1_2_3_29_2
  doi: 10.1126/science.1112125
– ident: e_1_2_3_59_2
  doi: 10.1038/nature01629
– ident: e_1_2_3_9_2
  doi: 10.1007/978-3-0348-7460-1_1
– ident: e_1_2_3_43_2
  doi: 10.1007/BF02540904
– ident: e_1_2_3_52_2
  doi: 10.1111/j.1749-6632.2002.tb02098.x
– ident: e_1_2_3_47_2
  doi: 10.2307/3571274
– ident: e_1_2_3_28_2
  doi: 10.1016/S0140-6736(05)61126-9
– ident: e_1_2_3_34_2
  doi: 10.1073/pnas.78.11.7124
– ident: e_1_2_3_51_2
  doi: 10.1096/fasebj.10.2.8641567
– start-page: 333
  volume-title: Handbook of Aging and the Individual
  year: 1955
  ident: e_1_2_3_5_2
  contributor:
    fullname: Jones H.R.
– ident: e_1_2_3_48_2
  doi: 10.1016/S0960-9822(02)00808-4
– ident: e_1_2_3_16_2
  doi: 10.1056/NEJMra021333
– ident: e_1_2_3_60_2
  doi: 10.1001/jama.289.19.2481
– ident: e_1_2_3_31_2
  doi: 10.1016/0047-6374(94)90104-X
– ident: e_1_2_3_10_2
  doi: 10.1023/B:BGEN.0000006561.15498.68
– ident: e_1_2_3_22_2
  doi: 10.1126/science.1106653
– ident: e_1_2_3_55_2
  doi: 10.1073/pnas.261708898
– ident: e_1_2_3_13_2
  doi: 10.1089/rej.1.1999.2.199
– volume: 23
  start-page: 147
  year: 2000
  ident: e_1_2_3_14_2
  article-title: Alzheimer's disease: a hypothesis on pathogenesis
  publication-title: J. Am. Aging Assoc
  contributor:
    fullname: Harman D.
– ident: e_1_2_3_41_2
  doi: 10.1016/j.toxlet.2003.12.017
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Snippet Aging is the progressive accumulation of diverse, deleterious changes with time that increase the chance of disease and death. The basic chemical process...
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StartPage 10
SubjectTerms Aging - physiology
Biological Evolution
Free Radicals - metabolism
Humans
Life Expectancy - trends
Longevity - physiology
Models, Biological
Mortality - trends
Title Free radical theory of aging: an update: increasing the functional life span
URI https://www.ncbi.nlm.nih.gov/pubmed/16803965
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Volume 1067
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