Effect of Th2 cytokines on ceramide subclasses based on a model of reconstructed human epidermis

• Published in: EJD. European journal of dermatology Vol. 34; no. 4; pp. 361 - 370
• Main Authors: Bakar, Joudi, Michael-Jubeli, Rime, Salmon, Michel, Lancelot, Céline, Baillet-Guffroy, Arlette, Tfayli, Ali
• Format: Journal Article
• Language: English
• Published: France 01.08.2024
• Subjects: Ceramides - analysis; Ceramides - metabolism; Cytokines - metabolism; Dermatitis, Atopic - drug therapy; Dermatitis, Atopic - metabolism; Epidermis - drug effects; Epidermis - metabolism; Humans; Interleukin-33 - metabolism; Interleukin-4 - metabolism; Models, Biological; Sphingosine - analogs & derivatives; Th2 Cells; Thymic Stromal Lymphopoietin; NP-LC/HR-MSn; atopic dermatitis; reconstructed human epidermis; ceramide analysis; Th2 cytokine
• ISSN: 1167-1122; 1952-4013; 1952-4013
• DOI: 10.1684/ejd.2024.4737

Atopic dermatitis (AD) is associated with chronic inflammation and an altered skin barrier. Lipids of the stratum corneum of AD patients are known to differ substantially in composition from those of healthy subjects. A reconstructed human epidermis (RHE) model has been developed in vitro in order t...