Efficacy of Gefitinib Combined with 125I Radioactive Particles in the Treatment of Transplanted Lung Cancer Tumors in Nude Mice

• Published in: Cardiovascular and interventional radiology Vol. 43; no. 9; pp. 1364 - 1370
• Main Authors: Li, Chaojie, Yao, Linyan, Gong, Ju, Pang, Haopeng, Shan, Qungang, Wang, Ziyin, Lu, Jian, Wang, Zhongmin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2020; Springer Nature B.V
• Subjects: Adenocarcinoma; Bioluminescence; Brachytherapy; Cardiology; Gefitinib; Imaging; Implantation; Inhibitor drugs; Interventional Oncology; Iodine; Iodine 125; Iodine isotopes; Iodine radioisotopes; Laboratory Investigation; Lung cancer; Lung transplantation; Medicine; Medicine & Public Health; Nuclear Medicine; Photons; Radiation therapy; Radiology; Reporter gene; Statistical analysis; Statistical significance; Surgical implants; Targeted cancer therapy; Tempering; Tumors; Ultrasound; I radioactive particles; fluorine-fluorinedeoxyglucose; Lung adenocarcinoma; Biofluorescence imaging; Gefitinib; F-FDG

Objective To investigate the efficacy of gefitinib combined with iodine-125 ( 125 I) radioactive particles in the treatment of transplanted tumors of the lung cancer cell line A549 in nude mice. Materials and Methods Twenty-four nude mice were inoculated with A549-luc human lung adenocarcinoma cells...