Research Progress on Embryonic Development, Genetic Regulation and Clinical Management of Congenital Middle Ear Malformations

• Published in: Flavour and fragrance journal Vol. 40; no. 3; pp. 393 - 401
• Main Authors: Gao, Xiaochen, Li, Chengzhilin, Yuan, Fanyu, Cao, Xue, Liu, Chengcheng, Qi, Wenwen, Xie, Fengyang, Xia, Ming
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.05.2025
• Subjects: Auditory defects; Cell migration; Congenital defects; Diagnosis; Ear; Ear canal; early diagnosis; Embryogenesis; Embryonic growth stage; Fibroblast growth factor 10; Fibroblast growth factor 8; flavor; genes; Genetic screening; Hearing aids; Hearing loss; Middle ear; Mutation; Neonates; Neural crest; odors; Point mutation; Quality of life; Regulatory mechanisms (biology); Signal transduction; Tbx1 protein

Congenital middle ear malformations are a common hearing defect in newborns, primarily characterised by abnormal middle ear structures, particularly underdeveloped or malformed ossicular chains, resulting in conductive hearing loss. This article provides a comprehensive review of the embryonic devel...