The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling

• Published in: Journal of steroid biochemistry and molecular biology Vol. 121; no. 1-2; pp. 355 - 361
• Main Authors: ORDONEZ-MORAN, Paloma, ALVAREZ-DIAZ, Silvia, VALLE, Noelia, LARRIBA, María Jesús, BONILLA, Félix, MUNOZ, Alberto
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Kidlington Elsevier 01.07.2010
• Subjects: Biological and medical sciences; Calcitriol - metabolism; Cell Line, Tumor; Cell Membrane - metabolism; Cell Proliferation; Colonic Neoplasms - metabolism; Cyclin D1 - metabolism; Cystatins - metabolism; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation, Neoplastic; Humans; Medical sciences; Membrane Proteins - metabolism; Microscopy, Confocal - methods; Occludin; p38 Mitogen-Activated Protein Kinases - metabolism; rho-Associated Kinases - metabolism; rhoA GTP-Binding Protein - metabolism; Ribosomal Protein S6 Kinases, 90-kDa - metabolism; Signal Transduction; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tight Junctions - metabolism; Tumors; Vertebrates: endocrinology; Vertebrates: reproduction; Cystatin; MSK; Steroid hormone; Cholecalciferol(1,25-dihydroxy); Gene regulation; Malignant tumor; RhoA; Micronutrient; Colonic disease; Signal transduction; Colon cancer; Gene; Vitamin D; Cystatin D; Digestive diseases; Intestinal disease; Cancer

Many studies support a protective action of vitamin D against colon cancer. 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) exerts wide gene regulatory effects in human colon cancer cells. We previously reported that 1,25(OH)2D3 increases cytosolic Ca2+ concentration and transiently activates RhoA and i...