Chronic inhibition of nuclear factor-κB attenuates renal injury in the 5/6 renal ablation model

• Published in: American journal of physiology. Renal physiology Vol. 292; no. 1; pp. F92 - F99
• Main Authors: Fujihara, Clarice K., Antunes, Gláucia R., Mattar, Ana L., Malheiros, Denise M. A. C., Vieira, José M., Zatz, Roberto
• Format: Journal Article
• Language: English
• Published: 01.01.2007

Recent studies indicated that the nuclear transcription factor, NF-κB, activates a number of proinflammatory genes in subjects with progressive nephropathies. We investigated whether NF-κB inhibition limits progressive renal injury in the 5/6 renal ablation model (Nx). Adult male Munich-Wistar rats...