Efficacy increase of lipid nanoparticles in vivo by inclusion of bis(monoacylglycerol)phosphate

• Published in: Nanomedicine (London, England) Vol. 17; no. 20; pp. 1399 - 1410
• Main Authors: Sagi, Amit, Mukthavaram, Rajesh, Recatto, River, Hong, Hyojung, Davis, Michael, Trelles, Ramon Diaz, El-Mecharrafie, Nadja, Acharya, Grishma, Gomez, Abraham, Leu, Angel, Tachikawa, Kiyoshi, Sacchetti, Cristiano, Soontornniyomkij, Benchawanna, Rajappan, Kumar, Karmali, Priya, Chivakula, Padmanabh
• Format: Journal Article
• Language: English
• Published: England 01.08.2022
• Subjects: Humans; Monoglycerides - metabolism; Nanoparticles - chemistry; Phosphates; RNA, Messenger; gene delivery; lipid nanoparticles; mRNA therapy; protein expression; bis(monoacylglycerol) phosphate

To investigate the effect of incorporating bis(monoacylglycerol)phosphate (BMP) lipid into a lipid nanoparticle and the functional transport of mRNA by the formulated nanoparticles . The nanoparticles were prepared from ionizable lipid, 1,2-distearoyl- -glycerol-3-phosphocholine, cholesterol, 1,2-di...