Histologic and immunohistochemical study of primary gastrointestinal lymphoma

• Published in: Journal of the Japan Society of the Reticuloendothelial System Vol. 31; no. 3; pp. 237 - 256
• Main Author: Ono, Nobutaka
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society for Lymphoreticular Tissue Research 1991
• Subjects: Histogenesis; Immunohistochemistry; MALT-lymphoma; Mucosa-associated lymphoid tissue; Primary gastrointestinal lymphoma
• ISSN: 0386-9725; 1883-6801
• DOI: 10.3960/jslrt1961.31.237

A total of 36 cases with gastrointestinal malignant lymphomas, consisting of 22 of stomach, 8 of small intestine, 3 of large intestine and 3 of multiple occurrence through the gut, were studied to characterize growth pattern, cytologic features and histogenesis by the use of histologic and immunohistochemical techniques. Phenotypically 33 cases were of B cell type and 3 of T cell type. Cases with high grade malignancy according to working formulation showed deeper invasion in the gut wall comparing to those of lower malignancy. According to LSG classification, 6 cases were of follicular and other 27 cases were of diffuse lymphoma in B cell type. Histologically diffuse large cell lymphoma was the most preponderant type as high as 31%. Immunohistochemical features of mantle zone lymphocytes with sIgM+, sIgD+, Leu-1+, Leu-8+ and ALPase+ were different from those of germinal centers with sIgM+ and CALLA+. Based on these findings, a histogenesis of primary B cell gastrointestinal lymphoma was histologically and phenotypically divided into three origins, pre-follicle center cell origin (mantle zone lymphocyte origin), follicle center cell origin and postfollicle center cell origin. Medium-sized lymphomas derived from mantle zone lymphocytes may have close similarity to those of mucosa-associated lymphoid tissue (MALT) lymphomas proposed by Isaacson et al.