Retracted: miR‐30d‐5p suppresses proliferation and autophagy by targeting ATG5 in renal cell carcinoma
Previous reports have shown that miR‐30d‐5p functions as a tumor suppressor in prostate cancer and gallbladder carcinoma, but its role in renal cell carcinoma (RCC) remains elusive. This study was designed to explore the functional role of miR‐30d‐5p in proliferation and autophagy of RCC. Our result...
Saved in:
| Published in | FEBS open bio Vol. 11; no. 2; pp. 529 - 540 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
John Wiley & Sons, Inc
01.02.2021
Wiley |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Previous reports have shown that miR‐30d‐5p functions as a tumor suppressor in prostate cancer and gallbladder carcinoma, but its role in renal cell carcinoma (RCC) remains elusive. This study was designed to explore the functional role of miR‐30d‐5p in proliferation and autophagy of RCC. Our results show that miR‐30d‐5p is significantly down‐regulated in RCC tissues compared with normal tissues. miR‐30d‐5p overexpression suppressed cell proliferation, cell‐cycle G1/S transition and autophagy, but promoted apoptosis in RCC cell lines (786‐O and ACHN). Intriguingly, autophagy‐related gene 5 (ATG5) was directly targeted by miR‐30d‐5p, as shown using luciferase reporter assay and biotin‐avidin pull‐down assay. Moreover, overexpression of ATG5 attenuated the inhibitory effect of miR‐30d‐5p on proliferation and autophagy in 786‐O cells. These results suggest that miR‐30d‐5p suppresses proliferation and autophagy in RCC cells by targeting ATG5, and this pathway may be a suitable basis for the design of novel cancer therapeutics. |
|---|---|
| AbstractList | Previous reports have shown that miR‐30d‐5p functions as a tumor suppressor in prostate cancer and gallbladder carcinoma, but its role in renal cell carcinoma (RCC) remains elusive. This study was designed to explore the functional role of miR‐30d‐5p in proliferation and autophagy of RCC. Our results show that miR‐30d‐5p is significantly down‐regulated in RCC tissues compared with normal tissues. miR‐30d‐5p overexpression suppressed cell proliferation, cell‐cycle G1/S transition and autophagy, but promoted apoptosis in RCC cell lines (786‐O and ACHN). Intriguingly, autophagy‐related gene 5 (ATG5) was directly targeted by miR‐30d‐5p, as shown using luciferase reporter assay and biotin‐avidin pull‐down assay. Moreover, overexpression of ATG5 attenuated the inhibitory effect of miR‐30d‐5p on proliferation and autophagy in 786‐O cells. These results suggest that miR‐30d‐5p suppresses proliferation and autophagy in RCC cells by targeting ATG5, and this pathway may be a suitable basis for the design of novel cancer therapeutics. Abbreviations ATG5 autophagy-related gene 5 CCK-8 Cell Counting Kit-8 MUT mutant NC negative control PI propidium iodide qRT-PCR quantitative RT-PCR RCC renal cell carcinoma SD standard deviation WT wild-type Renal cell carcinoma (RCC), including two main histological subtypes (clear cell RCC and papillary RCC) [ 1], is the third leading cause of urological malignancies, accounting for ~3% of all adult malignancies [ 2]. Despite great efforts having been made in multimodal approaches and strategies, the prognosis of patients with RCC still remains unsatisfactory [ 3,4]. [...]it is urgently imperative to investigate the molecular mechanisms underlying the pathogenesis of RCC to improve treatment and prognosis for patients with RCC. Next, the functional roles of miR-30d-5p in cell proliferation, cell-cycle progression, apoptosis and autophagy were investigated in RCC cells. [...]we explored whether ATG5 was a direct downstream regulator involved in miR-30d-5p regulating biological functions. Characteristics Cases (n = 25) Sex Male 17 Female 8 Age, yr <60 12 ≥60 13 Tumor size, cm <5 20 ≥5 5 Histological type Clear cell 22 Papillary 3 TNM stage I–II 19 III–IV 6 Lymph node metastasis Negative 21 Positive 4 Cell culture Human RCC cell lines (786-O, ACHN and Caki-1) and normal kidney cell line HK-2 were purchased from the American Type Culture Collection (Manassas, VA, USA). |
| Author | Liang, Liang Deng, Qian Yang, Zheng Jiang, Yazhuo Cheng, Yongyi Li, Lei Sun, Yi |
| Author_xml | – sequence: 1 givenname: Liang surname: Liang fullname: Liang, Liang organization: Department of Urology The First Affiliated Hospital of Xi'an Jiaotong University China, Medical College of Xi'an Jiao Tong University China – sequence: 2 givenname: Zheng surname: Yang fullname: Yang, Zheng organization: Department of Urology The First Affiliated Hospital of Xi'an Jiaotong University China – sequence: 3 givenname: Qian surname: Deng fullname: Deng, Qian organization: Department of Urology Shaanxi Provincial People's Hospital Xi'an China, Department of Urology The Third Affiliated Hospital of Xi'an Jiaotong University China – sequence: 4 givenname: Yazhuo surname: Jiang fullname: Jiang, Yazhuo organization: Department of Urology Shaanxi Provincial People's Hospital Xi'an China, Department of Urology The Third Affiliated Hospital of Xi'an Jiaotong University China – sequence: 5 givenname: Yongyi surname: Cheng fullname: Cheng, Yongyi organization: Department of Urology Shaanxi Provincial People's Hospital Xi'an China, Department of Urology The Third Affiliated Hospital of Xi'an Jiaotong University China – sequence: 6 givenname: Yi surname: Sun fullname: Sun, Yi organization: Department of Urology Shaanxi Provincial People's Hospital Xi'an China, Department of Urology The Third Affiliated Hospital of Xi'an Jiaotong University China – sequence: 7 givenname: Lei orcidid: 0000-0001-8706-6552 surname: Li fullname: Li, Lei organization: Department of Urology The First Affiliated Hospital of Xi'an Jiaotong University China |
| BookMark | eNp9UU1LXDEUDUVBq67dBroezef7cCfSWkEoiF2H-5KbaYY3L69JZjE7f4K_sb-kmZlWSqEN4SYczjlwz3lPjqY4ISGXnF1xxsS1EJwvtGrkFZdM6Hfk9A05-uN_Qi5yXrF6GsYbxk7J6glLAlvQ3dB1ePrx8iqZq1PPNG_mOWHOmOmc4hg8JighThQmR2FT4vwNlls6bGmBtMQSpiW9fb7XNEw04QQjtTjWAcmGKa7hnBx7GDNe_HrPyNdPH5_vPi8ev9w_3N0-LqxQvV4Mneq7wTrw7eCZkkMrtWgl9z1TTHll-wE7afseeSsqxEGKTkvnlffetq08Iw8HXxdhZeYU1pC2JkIweyCmpYFUgh3RACjRaM-GrlcKwYHzGm3jlLXgGOrq9eHgVRP4vsFczCpuUt0tG8lFjVrKRvyPJVTXccbrrSx9YNkUc07ojQ1ln2htIIyGM7Pr0uzaMru2zL7Lqrv-S_d7p38pfgJ6LaHk |
| CitedBy_id | crossref_primary_10_1016_j_trim_2022_101626 crossref_primary_10_1155_2022_4928635 crossref_primary_10_3389_fcell_2022_829435 crossref_primary_10_3892_or_2023_8592 crossref_primary_10_1155_2023_3187846 crossref_primary_10_3389_fvets_2022_909500 crossref_primary_10_1016_j_ebiom_2022_104108 crossref_primary_10_3390_ijms22052553 crossref_primary_10_3390_biomedicines10092060 crossref_primary_10_3390_biomedicines10061219 crossref_primary_10_3389_fonc_2022_1025192 crossref_primary_10_3724_zdxbyxb_2024_0504 crossref_primary_10_1016_j_heliyon_2024_e33835 crossref_primary_10_18632_aging_205587 crossref_primary_10_1002_cam4_5375 crossref_primary_10_1177_15330338241281310 crossref_primary_10_1007_s11033_024_09384_x crossref_primary_10_1007_s12033_022_00628_4 crossref_primary_10_1155_2024_5562293 |
| Cites_doi | 10.1016/j.canlet.2019.12.005 10.1016/j.bbcan.2019.08.001 10.1128/mBio.03045-19 10.1016/j.canlet.2015.03.041 10.1002/mc.22799 10.1042/CS20080508 10.1515/bmc-2017-0024 10.1158/1078-0432.CCR-07-5023 10.1038/nrclinonc.2011.71 10.1038/s41419-019-1446-z 10.1016/j.ccr.2012.02.019 10.1016/j.biopha.2018.04.193 10.1038/nature09204 10.4251/wjgo.v7.i11.271 10.2147/OTT.S209441 10.1007/s12282-019-00980-5 10.1016/j.bbrc.2016.04.054 10.1093/jnen/nlx052 10.1111/cas.14192 10.1016/j.lfs.2019.117238 10.1097/PPO.0b013e31829da0d6 10.7257/1053-816X.2012.32.4.182 10.1016/S1470-2045(16)30125-5 10.2147/CMAR.S232380 10.3322/caac.21442 10.1016/j.ccr.2006.06.001 10.1186/s11658-016-0031-z 10.3390/cancers11070986 10.1007/s00281-010-0222-z 10.1016/j.ccell.2014.09.015 10.1056/NEJMra1601333 10.1089/cbr.2018.2457 |
| ContentType | Journal Article |
| Copyright | 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | AAYXX CITATION 8FE 8FH ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M7P PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS DOA |
| DOI | 10.1002/2211-5463.13025 |
| DatabaseName | CrossRef ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Database ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea ProQuest Central Student SciTech Premium Collection ProQuest Biological Science Collection Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Biological Science Collection ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) |
| DatabaseTitleList | CrossRef Publicly Available Content Database Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2211-5463 |
| EndPage | 540 |
| ExternalDocumentID | oai_doaj_org_article_aa4265f0b8944eadadf5ec6d4ccad0e5 1010022211546313025 10_1002_2211_5463_13025 |
| Genre | Correction/Retraction |
| GroupedDBID | --- --K 0R~ 1OC 24P 4.4 53G 5VS 8FE 8FH AAEDT AAEDW AAFWJ AAHBH AAHHS AAIKJ AALRI AAXUO AAYWO AAYXX AAZKR ABMAC ACCFJ ACCMX ACVFH ACXQS ADBBV ADCNI ADEZE ADKYN ADPDF ADRAZ ADVLN ADZMN ADZOD AEEZP AENEX AEQDE AEUPX AEXQZ AFKRA AFPKN AFPUW AGHFR AIGII AITUG AIWBW AJBDE AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS ALUQN AMRAJ AOIJS AVUZU BBNVY BCNDV BENPR BHPHI CCPQU CITATION DIK EBS EJD EMOBN FDB GROUPED_DOAJ HCIFZ HYE HZ~ IAO IGS IHR INH IPNFZ ITC IXB KQ8 LK8 M41 M48 M7P M~E O-L O9- OK1 OVD OVEED PHGZM PHGZT PIMPY PROAC R9- RIG ROL RPM SSZ TEORI XH2 AAMMB ABUWG AEFGJ AGXDD AIDQK AIDYY AZQEC DWQXO GNUQQ PKEHL PQEST PQGLB PQQKQ PQUKI PRINS WIN PUEGO |
| ID | FETCH-LOGICAL-c2495-b8498bcdaf7bf043b7352731f90404f4c9be83c99e1720401a32853df4fffc773 |
| IEDL.DBID | M48 |
| ISSN | 2211-5463 |
| IngestDate | Wed Aug 27 01:29:23 EDT 2025 Wed Aug 13 07:37:20 EDT 2025 Wed Aug 13 07:37:25 EDT 2025 Tue Jul 01 01:14:11 EDT 2025 Thu Apr 24 23:10:54 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c2495-b8498bcdaf7bf043b7352731f90404f4c9be83c99e1720401a32853df4fffc773 |
| Notes | ObjectType-Correction/Retraction-1 SourceType-Scholarly Journals-1 content type line 14 |
| ORCID | 0000-0001-8706-6552 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1002/2211-5463.13025 |
| PQID | 2488101101 |
| PQPubID | 4368360 |
| PageCount | 12 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_aa4265f0b8944eadadf5ec6d4ccad0e5 proquest_journals_3123023362 proquest_journals_2488101101 crossref_citationtrail_10_1002_2211_5463_13025 crossref_primary_10_1002_2211_5463_13025 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-02-00 20210201 2021-02-01 |
| PublicationDateYYYYMMDD | 2021-02-01 |
| PublicationDate_xml | – month: 02 year: 2021 text: 2021-02-00 |
| PublicationDecade | 2020 |
| PublicationPlace | Amsterdam |
| PublicationPlace_xml | – name: Amsterdam |
| PublicationTitle | FEBS open bio |
| PublicationYear | 2021 |
| Publisher | John Wiley & Sons, Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: Wiley |
| References | e_1_2_10_24_1 e_1_2_10_21_1 e_1_2_10_20_1 Kim DY (e_1_2_10_7_1) 2017; 32 e_1_2_10_2_1 e_1_2_10_4_1 e_1_2_10_18_1 e_1_2_10_3_1 e_1_2_10_19_1 e_1_2_10_6_1 e_1_2_10_16_1 e_1_2_10_5_1 e_1_2_10_17_1 e_1_2_10_8_1 e_1_2_10_14_1 e_1_2_10_15_1 e_1_2_10_36_1 e_1_2_10_12_1 e_1_2_10_35_1 e_1_2_10_9_1 e_1_2_10_13_1 e_1_2_10_34_1 e_1_2_10_10_1 e_1_2_10_33_1 e_1_2_10_11_1 e_1_2_10_32_1 e_1_2_10_31_1 e_1_2_10_30_1 Yu X (e_1_2_10_22_1) 2018; 23 Yu M (e_1_2_10_23_1) 2020; 19 Xi Z (e_1_2_10_37_1) 2019; 54 e_1_2_10_29_1 e_1_2_10_27_1 e_1_2_10_28_1 e_1_2_10_25_1 e_1_2_10_26_1 |
| References_xml | – ident: e_1_2_10_19_1 doi: 10.1016/j.canlet.2019.12.005 – ident: e_1_2_10_9_1 doi: 10.1016/j.bbcan.2019.08.001 – ident: e_1_2_10_8_1 doi: 10.1128/mBio.03045-19 – ident: e_1_2_10_12_1 doi: 10.1016/j.canlet.2015.03.041 – volume: 32 start-page: 1 year: 2017 ident: e_1_2_10_7_1 article-title: Regulatory role of microRNAs in the proliferation and differentiation of adipose‐derived stem cells publication-title: Histol Histopathol – ident: e_1_2_10_13_1 doi: 10.1002/mc.22799 – ident: e_1_2_10_24_1 doi: 10.1042/CS20080508 – ident: e_1_2_10_6_1 doi: 10.1515/bmc-2017-0024 – ident: e_1_2_10_17_1 doi: 10.1158/1078-0432.CCR-07-5023 – ident: e_1_2_10_25_1 doi: 10.1038/nrclinonc.2011.71 – volume: 54 start-page: 239 year: 2019 ident: e_1_2_10_37_1 article-title: LncRNA MALAT1 potentiates autophagyassociated cisplatin resistance by regulating the microRNA30b/autophagyrelated gene 5 axis in gastric cancer publication-title: Int J Oncol – ident: e_1_2_10_21_1 doi: 10.1038/s41419-019-1446-z – ident: e_1_2_10_26_1 doi: 10.1016/j.ccr.2012.02.019 – ident: e_1_2_10_36_1 doi: 10.1016/j.biopha.2018.04.193 – ident: e_1_2_10_15_1 doi: 10.1038/nature09204 – volume: 19 start-page: 53 year: 2020 ident: e_1_2_10_23_1 article-title: MicroRNA‐30d‐5p promotes ovarian granulosa cell apoptosis by targeting Smad2 publication-title: Exp Ther Med – ident: e_1_2_10_28_1 doi: 10.4251/wjgo.v7.i11.271 – ident: e_1_2_10_32_1 doi: 10.2147/OTT.S209441 – ident: e_1_2_10_34_1 doi: 10.1007/s12282-019-00980-5 – ident: e_1_2_10_35_1 doi: 10.1016/j.bbrc.2016.04.054 – ident: e_1_2_10_20_1 doi: 10.1093/jnen/nlx052 – ident: e_1_2_10_18_1 doi: 10.1111/cas.14192 – ident: e_1_2_10_11_1 doi: 10.1016/j.lfs.2019.117238 – ident: e_1_2_10_31_1 doi: 10.1097/PPO.0b013e31829da0d6 – ident: e_1_2_10_2_1 doi: 10.7257/1053-816X.2012.32.4.182 – ident: e_1_2_10_4_1 doi: 10.1016/S1470-2045(16)30125-5 – ident: e_1_2_10_10_1 doi: 10.2147/CMAR.S232380 – ident: e_1_2_10_3_1 doi: 10.3322/caac.21442 – ident: e_1_2_10_16_1 doi: 10.1016/j.ccr.2006.06.001 – ident: e_1_2_10_30_1 doi: 10.1186/s11658-016-0031-z – ident: e_1_2_10_33_1 doi: 10.3390/cancers11070986 – ident: e_1_2_10_29_1 doi: 10.1007/s00281-010-0222-z – ident: e_1_2_10_27_1 doi: 10.1016/j.ccell.2014.09.015 – ident: e_1_2_10_5_1 doi: 10.1056/NEJMra1601333 – ident: e_1_2_10_14_1 doi: 10.1089/cbr.2018.2457 – volume: 23 start-page: 48 year: 2018 ident: e_1_2_10_22_1 article-title: Long non‐coding RNA PVT1 functions as an oncogene in human colon cancer through miR‐30d‐5p/RUNX2 axis publication-title: J BUON |
| SSID | ssj0000601600 |
| Score | 2.1787279 |
| SecondaryResourceType | retracted_publication |
| Snippet | Previous reports have shown that miR‐30d‐5p functions as a tumor suppressor in prostate cancer and gallbladder carcinoma, but its role in renal cell carcinoma... Abbreviations ATG5 autophagy-related gene 5 CCK-8 Cell Counting Kit-8 MUT mutant NC negative control PI propidium iodide qRT-PCR quantitative RT-PCR RCC renal... |
| SourceID | doaj proquest crossref |
| SourceType | Open Website Aggregation Database Enrichment Source Index Database |
| StartPage | 529 |
| SubjectTerms | ATG5 autophagy miR‐30d‐5p proliferation renal cell carcinoma |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA4iCF7EJ66ukoMHL9U2SbetNxUfCHqQXfAW8hRFu8s-DnvzJ_gb_SXOJF1ZUPHipYc0Je1kMt-kTL6PkAOhGUS8qkxsgUdyso5KSiFEwkSRG4AEWxk8KHx717nuiZuH_GFO6gtrwiI9cDTcsVKAIblPdVkJAZ-trM-d6VgBQ9vUBfZSwLy5zVSMwcicls64fFJ2zGCnkyD3O-ofozD2HAwFtv5vwTggzOUqWWlSQ3oaX2mNLLh6nSxFscjpBnm-d-PArWxP6OvT_cfbO08tXPMBHU0GoZ7VjegAVXi8i_NKVW2pmiB3gHqcUj2lsfAb4Iqedq9y-lTTocNB8f89NagrVPdf1SbpXV50z6-TRikhMagdnehSVKU2VvlC-1RwXXAkVst8BWtUeGEq7UpuqsplKEqTZoozwGnrhffeFAXfIot1v3bbhHKwMIMmk1kOqRTYHRKA3OTOOsVLVrTI0cxw0jQ04qhm8SIjATKTaGmJlpbB0i1y-PXAIDJo_N71DGfiqxtSX4cGcAjZOIT8yyFapD2bR9msx5FkEKcyTHWyH29zwG9IXgDMd_7jFXbJMsPSl1Dc3SaL4-HE7UHuMtb7wU0_Abck7Gc priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwELbaRZV6QbS06vKSDz1wSUlsZ-P0gnYRFFUqQiuQuFl-IlDJpvs47I2f0N_YX9IZx7sg9XHJwXEemvE8Mhl_HyEfhWHg8WqZuQq35BQDnUkhRMZEVVoICa62uFH428Xg_Fp8vSlvUsFtltoqVz4xOmo3sVgjP-LgYiG-gL89bn9kyBqFf1cThcZLsgEuWMoe2RidXlyO11WWiDaS5ytMn5wdMfjiyRADHnmQkSD7WTiKqP1_OOUYac62yGZKEemw0-kb8sI3b8mrjjRyuU3ux34eMZbdZ_pwN_71-JPnDo5lS2eLNva1-hltkY0n-E6_VDeO6gViCOjbJTVL2jWAQ9iiw6svJb1r6NTjQ7GOTy3yCzWTB_2OXJ-dXp2cZ4kxIbPIIZ0ZKWpprNOhMiEX3FQcAdaKUIOtiiBsbbzktq59geQ0eaE5g3jtgggh2Kri70mvmTT-A6HcacdgyBaOQ0qVGwmJQGlL77zmklV98mklOGUTnDiyWnxXHRAyUyhphZJWUdJ9cri-oO2QNP49dYSaWE9DCOw4MJneqmRRSmtILsoAL1YLAfagXSi9HTgBa9LlHm6yt9KjSnY5Uwz8VYEpT_HX00-LbOf_p3fJa4bNLbF9e4_05tOF34fsZG4O0hL8DeO14uU priority: 102 providerName: ProQuest |
| Title | Retracted: miR‐30d‐5p suppresses proliferation and autophagy by targeting ATG5 in renal cell carcinoma |
| URI | https://www.proquest.com/docview/2488101101 https://www.proquest.com/docview/3123023362 https://doaj.org/article/aa4265f0b8944eadadf5ec6d4ccad0e5 |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS-RAEG5cZWEv4qrL-tihDx68RJN-TBJBRBcfCIoMDnhr-imKZsZ5gHPzJ_gb_SVWdTIuouslh053Eqq6ur4O1d9HyIYwDFa8skhcjkdysrZOCiFEwkQuLaQEV1o8KHx23j7pitMrefVPDqgx4PDTrR3qSXUHd1uPD5M9CPjdhkB0m8EmJkFad5Q2ZvIbmYO0lKOcwVmD9etlGcnU0im9z8dx7zJTJPD_sD7HpHO0QOYbtEj3a_f-JDO-WiTfa_3IyRK57fhRpFt2O_T-pvPy9MxTB1fZp8NxP5a4-iHtozBP8LWrqa4c1WOkE9DXE2omtK4FhwxG9y-PJb2p6MDjS_GXPrUoNVT17vUy6R4dXv49SRrxhMSinHRiClEWxjodchNSwU3OkWstCyWErQjClsYX3Jalz1CnJs00Z5C6XRAhBJvn_BeZrXqV_00od9oxaLKZ44CuUlMAJpBWeuc1L1i-QramhlO2YRZHgYs7VXMiM4WWVmhpFS29QjbfBvRrUo3_dz1AT7x1Qzbs2NAbXKsmuJTWgDNkgA8rhYDQ0C5Ib9tOwPR0qYeHrE_9qKYzTDFYujJEP9mntzmkdMAzkN9Xv769Rn4wrHOJldzrZHY0GPs_AFRGpkXmDg7PLzqtuNFvxen4Cq1B5mE |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbKVgguiKcoFPABJC6hju1sEiSEWmjZ0naFVlupN9fPqohmwz6E9sZP4Jfwo_glzDjJgsTj1ksOtuNE4_HM2B5_HyFPpeFg8coicTleyUn7OimklAmXeWbBJbjS4kXho2F_cCzfn2Qna-R7dxcG0yo7mxgNtZtY3CPfEmBiwb-AvX1df06QNQpPVzsKjUYtDvzyCyzZZq_238L4PuN8b3f8ZpC0rAKJRZ7lxBSyLIx1OuQmMClMLhCELA0l6LMM0pbGF8KWpU-RwIWlWnDwaS7IEILNcwH9XiHrUvQZ75H1nd3hh9FqVyeimzDWYQgxvsVhhZUg5jzyLiMh92_uL7IE_OEEomfbu0lutCEp3W506BZZ89VtcrUhqVzeIR9Hfh4xnd1LenE--vH1m2AOnllNZ4s65tH6Ga2R_Sf4Rp-orhzVC8Qs0GdLapa0STgHN0m3x-8yel7RqceP4rkBtchnVE0u9F1yfCmyvEd61aTy9wkVTjsORTZ1AkI4ZgoIPDKbeee1KHi-QV50glO2hS9HFo1PqgFe5golrVDSKkp6gzxfvVA3yB3_brqDI7FqhpDbsWAyPVPtDFZaQzCTBfixUkqYf9qFzNu-kzAHHPPQyWY3jqq1AzPFwT6mGGKlf63-pdQP_l_9hFwbjI8O1eH-8OAhuc4xsSamjm-S3ny68I8gMpqbx606UnJ62TPgJ7UdHtk |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrUBcEE9RKOADSFzCJrazSZAQammXlsKqWrVSb66fVRHNhn0I7Y2fwO_h5_BLmMljQeJx6yUH23Gi8XhmbI-_D-CpNBwtXpFHLqMrOclAR7mUMuIySy26BFdYuij8YTTYO5bvTtKTNfje3YWhtMrOJtaG2k0s7ZH3BZpY9C9ob_uhTYs43Bm-rj5HxCBFJ60dnUajIgd--QWXb7NX-zs41s84H-4evdmLWoaByBLncmRyWeTGOh0yE2IpTCYIkCwJBeq2DNIWxufCFoVPiMwlTrTg6N9ckCEEm2UC-70C6xmtinqwvr07OhyvdnhqpJM47vCEYt7nuNqKCH-eOJiJnPs3V1gzBvzhEGovN7wJN9rwlG01-nQL1nx5G642hJXLO_Bx7Oc1vrN7yS7Oxz--fhOxw2dasdmiqnNq_YxVxAQUfKNbTJeO6QXhF-izJTNL1iSfo8tkW0dvU3Zesqmnj9IZArPEbVROLvRdOL4UWd6DXjkp_X1gwmnHscgmTmA4F5scg5DUpt55LXKebcCLTnDKtlDmxKjxSTUgzFyRpBVJWtWS3oDnqxeqBsXj3023aSRWzQh-uy6YTM9UO5uV1hjYpAF_rJAS56J2IfV24CTOBxd77GSzG0fV2oSZ4mgrEwq3kr9W_1LwB_-vfgLXUPPV-_3RwUO4zinHps4i34TefLrwjzBImpvHrTYyOL3sCfAT9bcjDg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Retracted%3A+miR%E2%80%9030d%E2%80%905p+suppresses+proliferation+and+autophagy+by+targeting+ATG5+in+renal+cell+carcinoma&rft.jtitle=FEBS+open+bio&rft.au=Liang%2C+Liang&rft.au=Yang%2C+Zheng&rft.au=Deng%2C+Qian&rft.au=Jiang%2C+Yazhuo&rft.date=2021-02-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.eissn=2211-5463&rft.volume=11&rft.issue=2&rft.spage=529&rft.epage=540&rft_id=info:doi/10.1002%2F2211-5463.13025&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=1010022211546313025 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2211-5463&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2211-5463&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2211-5463&client=summon |