Gastrointestinal absorption, tissue retention, and urinary excretion of dietary aluminum in rats determined by using 26Al

We used accelerator mass spectrometry (AMS) and 26AI to study the plasma concentration, urinary excretion, and retention in bone, brain, and liver of a single dose of a dietary concentration of aluminum ingested either with or without citrate by 2-month-old Wistar rats. In the absence of citrate, cu...

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Published inClinical chemistry (Baltimore, Md.) Vol. 43; no. 6; pp. 1023 - 1028
Main Authors Jouhanneau, Philippe, Raisbeck, Grant M, Yiou, Francoise, Lacour, Bernard, Banide, Helene, Drueke, Tilman B
Format Journal Article
LanguageEnglish
Published Washington, DC Am Assoc Clin Chem 01.06.1997
American Association for Clinical Chemistry
Subjects
Albumins - pharmacokinetics
Albuminuria - urine
Animals
Biological and medical sciences
Brain - metabolism
Diet
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Intestinal Absorption - physiology
Liver - metabolism
Male
Mass Spectrometry
Radioisotopes
Rats
Rats, Wistar
Serum Albumin - metabolism
Time Factors
Tissue Distribution
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Excretion
Rat
Rodentia
Citrate
Environmental factor
Aluminium
Radioisotope
Vertebrata
Mammalia
Absorption
Investigation method
Mass spectrometry
Nutritional status
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Summary:We used accelerator mass spectrometry (AMS) and 26AI to study the plasma concentration, urinary excretion, and retention in bone, brain, and liver of a single dose of a dietary concentration of aluminum ingested either with or without citrate by 2-month-old Wistar rats. In the absence of citrate, cumulative urinary excretion and skeleton retention were each approximately 0.05% of the total 26AI dose ingested. 26AI retention in brain and liver were approximately 4 x 10(-8) and 2 x 10(-6), respectively. Concomitant citrate intake increased these median values by about two- to fivefold, although this factor was highly variable in individual rats. Independent of citrate administration, 90% of the 26AI excreted in urine (measured cumulatively over 30 days) was excreted within the first 48 h. Uptake by bone was rapid (approximately 1 h) and permanent over the 30-day duration of the experiment.
Bibliography:ObjectType-Article-1
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ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/43.6.1023