The androgen receptor amino-terminal domain: structure, function and therapeutic potential

• Published in: Endocrine oncology Vol. 5; no. 1; p. e240061
• Main Authors: Hunter, Irene, Jamieson, Craig, McEwan, Iain J
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.01.2025; Bioscientifica
• Subjects: androgen receptor; endocrine therapy resistance; prostate; Review; endocrine therapy resistance; prostate; androgen receptor

Signalling by the steroid hormone testosterone involves the androgen receptor (AR), a structurally dynamic protein. The amino-terminal domain of the AR makes up more than half of the protein and has been found to be intrinsically disordered. This structural plasticity mediates receptor-dependent tra...