Analysis of Cannabidiol, Δ9-Tetrahydrocannabinol, and Their Acids in CBD Oil/Hemp Oil Products
Hemp products are readily available and are aggressively marketed for their health and medicinal benefits. Most consumers of these products are interested because of cannabidiol (CBD), which has taken the natural products industry by storm. The CBD and Δ 9 -tetrahydrocannabinol (Δ 9 -THC) concentrat...
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Published in | Medical cannabis and cannabinoids Vol. 3; no. 1; pp. 1 - 13 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Basel, Switzerland
S. Karger AG
13.08.2020
Karger Publishers |
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Abstract | Hemp products are readily available and are aggressively marketed for their health and medicinal benefits. Most consumers of these products are interested because of cannabidiol (CBD), which has taken the natural products industry by storm. The CBD and Δ 9 -tetrahydrocannabinol (Δ 9 -THC) concentrations in these products are often absent, and even where labeled, the accuracy of the label amounts is often questionable. In order to gain a better understanding of the CBD content, fifty hemp products were analyzed by gas chromatography coupled with mass spectrometry (GC-MS) for CBD, Δ 9 -THC, tetrahydrocannabinolic acid (Δ 9 -THCAA), and cannabidiolic acid (CBDA). Δ 9 -THCAA and CBDA are the natural precursors of Δ 9 -THC and CBD in the plant material. Decarboxylation to Δ 9 -THC and CBD is essential to get the total benefit of the neutral cannabinoids. Therefore, analysis for the neutral and acid cannabinoids is important to get a complete picture of the chemical profile of the products. The GC-MS method used for the analysis of these products was developed and validated. A 10-m × 0.18-mm DB-1 (0.4 μ film) column was used for the analysis. The majority of the hemp products were oils, one of the products was hemp butter, one was a concentrated hemp powder capsule, and another was a hemp extract capsule. Most of the products contained less than 0.1% CBD and less than 0.01% Δ 9 -THC. Three products contained 0.1–1% CBD, and 2 products contained 0.1–0.9% Δ 9 -THC. All of the samples appeared to be decarboxylated since the CBDA and Δ 9 -THCAA results were less than 0.001%. The developed method is simple, sensitive, and reproducible for the detection of Δ 9 -THC, Δ 9 -THCAA, CBD, and CBDA in CBD oil/hemp products. |
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AbstractList | Hemp products are readily available and are aggressively marketed for their health and medicinal benefits. Most consumers of these products are interested because of cannabidiol (CBD), which has taken the natural products industry by storm. The CBD and Δ9-tetrahydrocannabinol (Δ9-THC) concentrations in these products are often absent, and even where labeled, the accuracy of the label amounts is often questionable. In order to gain a better understanding of the CBD content, fifty hemp products were analyzed by gas chromatography coupled with mass spectrometry (GC-MS) for CBD, Δ9-THC, tetrahydrocannabinolic acid (Δ9-THCAA), and cannabidiolic acid (CBDA). Δ9-THCAA and CBDA are the natural precursors of Δ9-THC and CBD in the plant material. Decarboxylation to Δ9-THC and CBD is essential to get the total benefit of the neutral cannabinoids. Therefore, analysis for the neutral and acid cannabinoids is important to get a complete picture of the chemical profile of the products. The GC-MS method used for the analysis of these products was developed and validated. A 10-m × 0.18-mm DB-1 (0.4 μ film) column was used for the analysis. The majority of the hemp products were oils, one of the products was hemp butter, one was a concentrated hemp powder capsule, and another was a hemp extract capsule. Most of the products contained less than 0.1% CBD and less than 0.01% Δ9-THC. Three products contained 0.1–1% CBD, and 2 products contained 0.1–0.9% Δ9-THC. All of the samples appeared to be decarboxylated since the CBDA and Δ9-THCAA results were less than 0.001%. The developed method is simple, sensitive, and reproducible for the detection of Δ9-THC, Δ9-THCAA, CBD, and CBDA in CBD oil/hemp products. Hemp products are readily available and are aggressively marketed for their health and medicinal benefits. Most consumers of these products are interested because of cannabidiol (CBD), which has taken the natural products industry by storm. The CBD and Δ 9 -tetrahydrocannabinol (Δ 9 -THC) concentrations in these products are often absent, and even where labeled, the accuracy of the label amounts is often questionable. In order to gain a better understanding of the CBD content, fifty hemp products were analyzed by gas chromatography coupled with mass spectrometry (GC-MS) for CBD, Δ 9 -THC, tetrahydrocannabinolic acid (Δ 9 -THCAA), and cannabidiolic acid (CBDA). Δ 9 -THCAA and CBDA are the natural precursors of Δ 9 -THC and CBD in the plant material. Decarboxylation to Δ 9 -THC and CBD is essential to get the total benefit of the neutral cannabinoids. Therefore, analysis for the neutral and acid cannabinoids is important to get a complete picture of the chemical profile of the products. The GC-MS method used for the analysis of these products was developed and validated. A 10-m × 0.18-mm DB-1 (0.4 μ film) column was used for the analysis. The majority of the hemp products were oils, one of the products was hemp butter, one was a concentrated hemp powder capsule, and another was a hemp extract capsule. Most of the products contained less than 0.1% CBD and less than 0.01% Δ 9 -THC. Three products contained 0.1–1% CBD, and 2 products contained 0.1–0.9% Δ 9 -THC. All of the samples appeared to be decarboxylated since the CBDA and Δ 9 -THCAA results were less than 0.001%. The developed method is simple, sensitive, and reproducible for the detection of Δ 9 -THC, Δ 9 -THCAA, CBD, and CBDA in CBD oil/hemp products. |
Author | ElSohly, Mahmoud A. Murphy, Timothy P. Walker, Larry W. Gul, Waseem Khan, Ikhlas |
AuthorAffiliation | b National Center for Natural Products Research (NCNPR), School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA a ElSohly Laboratories, Inc., Oxford, Mississippi, USA d Department of Biomolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA c Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA |
AuthorAffiliation_xml | – name: b National Center for Natural Products Research (NCNPR), School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA – name: a ElSohly Laboratories, Inc., Oxford, Mississippi, USA – name: c Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA – name: d Department of Biomolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA |
Author_xml | – sequence: 1 givenname: Mahmoud A. surname: ElSohly fullname: ElSohly, Mahmoud A. email: *Mahmoud A. ElSohly, ElSohly Laboratories, Inc., 5 Industrial Park Dr., Oxford, MS 38655 (USA), elsohly@elsohly.com – sequence: 2 givenname: Timothy P. surname: Murphy fullname: Murphy, Timothy P. – sequence: 3 givenname: Ikhlas surname: Khan fullname: Khan, Ikhlas – sequence: 4 givenname: Larry W. surname: Walker fullname: Walker, Larry W. – sequence: 5 givenname: Waseem surname: Gul fullname: Gul, Waseem |
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Cites_doi | 10.1038/sj.bjp.0707442 10.1007/s40429-017-0142-2 10.1016/j.drugpo.2013.08.010 10.1001/jama.2015.6613 10.1124/pr.110.003004 10.1001/jama.2017.11909 10.1080/02791072.2014.944960 10.1016/j.schres.2011.04.017 |
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Keywords | Cannabidiol oil Cannabidiol Δ9-Tetrahydrocannabinol Gas chromatography coupled with mass spectrometry Hemp products |
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Title | Analysis of Cannabidiol, Δ9-Tetrahydrocannabinol, and Their Acids in CBD Oil/Hemp Oil Products |
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