Characterization and distribution of somatostatin SS-1 and SRIF-1 binding sites in rat brain: identitity with SSTR-2 receptors

• Published in: European journal of pharmacology. Molecular pharmacology section Vol. 289; no. 1; pp. 163 - 173
• Main Authors: Schoeffter, P., Pérez, J., Langenegger, D., Schüpbach, E., Bobirnac, I., Lübbert, H., Bruns, C., Hoyer, D.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.03.1995; Elsevier
• Subjects: Adenylate cyclase; Biological and medical sciences; Cell receptors; Cell structures and functions; Fundamental and applied biological sciences. Psychology; In situ hybridization; Molecular and cellular biology; Neuropeptide receptors; Receptor autoradiography; Recombinant SSTR-2 receptor; Somatostatin; SRIF-1 binding site; SS-1 binding site; Adenylate cyclase; Recombinant SSTR-2 receptor; Somatostatin; Receptor autoradiography; SRIF-1 binding site; In situ hybridization; SS-1 binding site; Rat; Enzyme; Peptide hormone; Rodentia; Central nervous system; Phosphorus-oxygen lyases; Lyases; Binding site; Neuropeptide; In vitro; Characterization; Vertebrata; Mammalia; Distribution; Peptidergic receptor; Recombinant protein; Molecular cloning

Somatostatin (SRIF) SS-1 binding sites were initially defined in radioligand binding studies performed in rat brain cerebral cortex membranes using [ 125I]204-090 (a radiolabelled Tyr 3 analogue of SMS 201-995, octreotide). SRIF-1 recognition sites were defined in binding studies performed with [ 12...