Creatinine normalization approach to diluted urine samples screened by LC-MS/MS method

• Published in: International Journal of Medical Biochemistry Vol. 7; no. 2; pp. 95 - 100
• Main Authors: Karakukcu, Cigdem, Kocer, Derya, Uzen, Veysel, Saracoglu, Hatice
• Format: Journal Article
• Language: English
• Published: Istanbul KARE Publishing 2024; Kare Publishing
• Subjects: Analysis; Collaboration; Creatinine; Laboratories; Medical screening; Methods; Urine

Objectives: Urine is the most used matrix in drug analysis; however, it is susceptible to adulteration or tampering. Urine creatinine is the most important urine integrity parameter used as an indicator of dilution. This study aimed to evaluate the prevalence of diluted urine samples and the change...