POSSIBLE RELATIONSHIP BETWEEN ALTERED FATTY ACID COMPOSITION OF SERUM, PLATELETS, AND AORTA AND HYPERTENSION INDUCED BY SUGAR FEEDING IN RATS

To establish a relationship between alterations in fatty acid metabolism, induced by sugar ingestion, and hypertension, we analyzed fatty acid composition of serum, platelets and aorta in rats which had 30% of sugar in their drinking water for 18-20 weeks, and became hypertensive, hypertriglyceridem...

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Published inClinical and experimental hypertension (1993) Vol. 22; no. 1; pp. 205 - 215
Main Authors Hafidi, El Mohammed, Valdez, Raúl, Baños, Guadalupe
Format Journal Article
LanguageEnglish
Published Informa UK Ltd 2000
Taylor & Francis
Subjects
blood pressure
fatty acid composition
Sugar ingestion
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Summary:To establish a relationship between alterations in fatty acid metabolism, induced by sugar ingestion, and hypertension, we analyzed fatty acid composition of serum, platelets and aorta in rats which had 30% of sugar in their drinking water for 18-20 weeks, and became hypertensive, hypertriglyceridemic and hyperinsulinemic. The fatty acid composition in sugar-fed as compared with that from control rats was as follows: in serum phospholipids, triglycerides and cholesterol ester fractions, palmitic, palmitoleic, oleic and cis-11-eicosadecaenoic acids were present in a higher proportion. In serum phospholipid fraction linoleic and arachidonic acids were decreased and a significant increase was observed in the proportion of dihomo-γ-linolenic acid. In the membrane phospholipids of platelets and aorta, higher proportions of palmitoleic and of oleic acids were observed. Differences in fatty acid composition of phospholipids between sugar-fed and control rats are consistent with altered membrane fluidity. Altered membrane function is a potential mechanism involved hypertension in rats.in sugar-induced
ISSN:1064-1963
1525-6006
DOI:10.1081/CEH-100100065