Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment

• Published in: Science advances Vol. 10; no. 22; p. eadn0235
• Main Authors: Skillin, Nathaniel P, Kirkpatrick, Bruce E, Herbert, Katie M, Nelson, Benjamin R, Hach, Grace K, Günay, Kemal Arda, Khan, Ryan M, DelRio, Frank W, White, Timothy J, Anseth, Kristi S
• Format: Journal Article
• Language: English
• Published: United States AAAS 31.05.2024
• Subjects: Animals; Anisotropy; Cell Differentiation; Cell Line; Extracellular Matrix; Mice; Muscle Contraction - physiology; Muscle Fibers, Skeletal - physiology; Myoblasts - cytology; Science & Technology - Other Topics

The ability of cells to organize into tissues with proper structure and function requires the effective coordination of proliferation, migration, polarization, and differentiation across length scales. Skeletal muscle is innately anisotropic; however, few biomaterials can emulate mechanical anisotro...