Mechanistic Studies of Carbon Monoxide Release from Norborn-2-en-7-one CORMs

• Published in: Asian journal of organic chemistry Vol. 11; no. 10
• Main Authors: Bell, Nathan T., Payne, China M., Sammut, Ivan A., Larsen, David S.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.10.2022
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; Prodrugs; INJURY; STRUCTURAL-CHARACTERIZATION; REPERFUSION; CARDIOPULMONARY BYPASS; DAMAGE; MOLECULES; CHEMICAL STRATEGY; Reaction mechanism; Drug design; Carbon monoxide; CLICK; CO-RELEASE

A study has been performed to determine the factors that control carbon monoxide (CO) release from 3a-bromo-norborn-2-en-7-one-based organic CO-releasing molecules (oCOms). Such molecules have recently become of interest for the therapeutic potential of targeted delivery of the gasotransmitter CO, h...