Ventricular violation increases the risk of leptomeningeal disease in cavity-directed radiosurgery treated patients

• Published in: Journal of radiation oncology Vol. 8; no. 1; pp. 23 - 29
• Main Authors: DePaoli, Bradley, Gozal, Yair M., Pater, Luke E., Breneman, John C., Warnick, Ronald E., Elson, Joshua, Struve, Timothy D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2019; Springer Nature B.V
• Subjects: Brain; Cancer Research; Demographics; Imaging; Medicine; Medicine & Public Health; Metastasis; Multivariate analysis; Oncology; Original Research; Patients; Radiation therapy; Radiology; Radiotherapy; Risk analysis; Surgery; Surgical Oncology; Survival; Fractionated stereotactic radiosurgery; Surgical resection; Brain metastases; Leptomeningeal; Ventricular violation

Purpose Stereotactic radiosurgery is increasingly used in patients with limited brain metastases and good baseline performance to avoid the toxicities of whole brain radiotherapy (WBRT). Patients with resected brain metastases are undergoing cavity-directed radiosurgery, withholding WBRT. Multiple i...