Exposing Differentiated Osteoblast-Like MC3T3-E1 Cells to Extremely Low-Frequency Electric Fields Has Calcification-Promoting Effects

• Published in: IEEE transactions on dielectrics and electrical insulation Vol. 31; no. 2; pp. 642 - 648
• Main Authors: Hamasaki, Takeki, Teruya, Kiichiro, Katakura, Yoshinori
• Format: Journal Article
• Language: English
• Published: New York IEEE 01.04.2024; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Alkaline phosphatase; Bones; Calcification; Calcium; calcium deposition; cell culture; Dielectrics and electrical insulation; electric field (EF); Electric fields; Electric potential; Exposure; extremely low-frequency EF (ELFEF); Fragility; Gene expression; LF electric fields; Medical treatment; Osteoblasts; Osteoporosis

In this study, the first to investigate the potential of using extremely low-frequency electric fields (ELFEFs) to improve osteoporosis, we examined the effects of ELFEF exposure on bone formation using osteoblast-like MC3T3-E1 cells. We first constructed a system to regulate the intensity of the EL...